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Extraction and Purification of Polyphenols from Freeze-dried Berry Powder for the Treatment of Vascular Smooth Muscle Cells In Vitro
Published on: July 5, 2017
Polyphenols with anti-proliferative activities from Penthorum chinense Pursh
Doudou Huang1, Yun Jiang2, Wansheng Chen3
1Department of Identification of Traditional Chinese Medicine, School of Pharmacy, Second Military Medical University, Shanghai 200433, China. hdd890920@163.com.
Abstract:
Two new polyphenols, penthorumin C (1) and 2,6-dihydroxyacetophenone-4-O- [4',6'-(S)-hexahydroxydiphenoyl]-β-D-glucose (2), along with four known polyphenolic acids, pinocembrin-7-O-[4",6"-hexahydroxydiphenoyl]-β-D-glucose(3), pinocembrin-7-O-[3"-O- galloyl- 4",6"-hexahydroxydiphenoyl]-β-D-glucose (4), thonningianin A (5), and thonningianin B (6) were isolated from Penthourm chinense. All compounds were evaluated for their anti-proliferative activity in HSC-T6 cells, and 2 and 5 showed significant activity, with IC50 values of 12.7 and 19.2 μM, respectively.
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