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Updated: Apr 26, 2026

Developing a Rat Model for Bipolar Disorder
Published on: May 2, 2025
Decreased plasma neurotrophin-4/5 levels in bipolar disorder patients in mania
Izabela G Barbosa1, Isabela B Morato1, Rodrigo B Huguet2
1Interdisciplinary Laboratory of Medical Investigation, School of Medicine, Universidade Federal de Minas Gerais (UFMJ), Belo Horizonte, MG, Brazil.
Objective:
To evaluate two poorly explored neurotrophins (NT), NT-3 and NT-4/5, in bipolar disorder (BD).
Methods:
Forty patients with type I BD (18 in remission and 22 in mania) and 25 healthy controls matched for age, gender, and educational attainment were enrolled in this study. All subjects were assessed by the Mini-International Neuropsychiatric Interview; the Young Mania Rating Scale and the Hamilton Depression Rating Scale were used to evaluate severity of symptoms in BD patients. Plasma levels of NT-3 and NT-4/5 were measured by enzyme-linked immunosorbent assay (ELISA).
Results:
BD patients in mania presented decreased NT-4/5 plasma levels in comparison with controls (p < 0.05). There were no significant differences in NT-3 plasma levels between BD patients and controls.
Conclusion:
These findings corroborate the view that neurotrophin dysfunction is associated with mood states in patients with BD.
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