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Meclofenamate increases ventilation in lambs.

F A Guerra¹, R D Savich, R I Clyman

¹Cardiovascular Research Institute, University of California, San Francisco.

Journal of Developmental Physiology

|January 1, 1989

Summary

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Meclofenamate, a prostaglandin synthetase inhibitor, increases postnatal ventilation in lambs by raising breathing rate. This effect occurs without altering blood gases or tidal volume, suggesting potential impacts on CO2 production or dead space ventilation.

Area of Science:

Neonatal Physiology
Respiratory Regulation
Pharmacology

Background:

Prostaglandins play a role in respiratory control.
Non-steroidal anti-inflammatory drugs (NSAIDs) can affect physiological processes.
Postnatal respiratory adaptation is critical for lamb survival.

Purpose of the Study:

To determine the impact of meclofenamate on ventilation in newborn lambs.
To investigate the effects of prostaglandin synthetase inhibition on respiratory parameters.
To assess changes in breathing rate and tidal volume following meclofenamate administration.

Main Methods:

Eleven unsedated, spontaneously breathing lambs were studied.
Meclofenamate was administered via intravenous infusion over 4 hours.

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Ventilation, breathing rate, tidal volume, heart rate, blood pressure, arterial pH, and PaCO2 were monitored.

Main Results:

Meclofenamate significantly increased overall ventilation (P < 0.05) due to a higher breathing rate.
Tidal volume, heart rate, blood pressure, arterial pH, and PaCO2 remained unchanged.
The increase in ventilation was observed irrespective of electrocortical activity levels.

Conclusions:

Meclofenamate administration leads to increased ventilation in lambs.
The observed increase in ventilation is attributed to an elevated respiratory rate.
The precise mechanism and location of meclofenamate's action on ventilation require further investigation.