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Elderly patients with pancreatic cancer
Andromachi S Kougioumtzopoulou1, Kostas N Syrigos, Muhammad Wasif Saif
1Radiotherapy Unit, Second Department of Radiology, Attikon General Hospital. Athens, Greece. andromachi.kou@gmail.com.
Elderly patients with advanced pancreatic cancer may benefit from specific treatments. Systemic therapy improved survival for pancreatic adenocarcinoma, while octreotide-LAR improved survival for neuroendocrine pancreatic tumors.
Area of Science:
- Oncology
- Geriatric Medicine
- Gastroenterology
Background:
- Pancreatic cancer incidence is rising in the elderly.
- No international guidelines exist for elderly pancreatic cancer patients.
- Two studies presented at ASCO 2014 addressed elderly populations.
Purpose of the Study:
- To evaluate the impact of systemic treatment on overall survival in elderly patients with stage IV pancreatic adenocarcinoma.
- To assess the effect of somatostatin analogue (octreotide-LAR) on overall survival in elderly patients with neuroendocrine pancreatic carcinoma.
Main Methods:
- Retrospective analysis of data from elderly patients with pancreatic cancer.
- Study 1 focused on stage IV pancreatic adenocarcinoma.
- Study 2 focused on neuroendocrine pancreatic carcinoma.
Main Results:
- Systemic treatment demonstrated a survival benefit for elderly patients with stage IV pancreatic adenocarcinoma (Abstract #4119).
- Octreotide-LAR treatment showed a positive effect on overall survival for elderly patients with neuroendocrine pancreatic carcinoma (Abstract #4112).
Conclusions:
- Systemic therapy is beneficial for elderly patients with advanced pancreatic adenocarcinoma.
- Octreotide-LAR may improve survival outcomes in elderly patients with neuroendocrine pancreatic carcinoma.
- Further research and guidelines are needed for elderly pancreatic cancer patients.
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