Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Sedatives and Hypnotics: Overview01:23

Sedatives and Hypnotics: Overview

2.2K
Sedatives are drugs that alleviate anxiety, while hypnotics induce sleep. Both classes of medication suppress neuronal activity, leading to a calming effect for sedatives and facilitating sleep for hypnotics.
Sedative-hypnotics are categorized into barbiturates, benzodiazepines (BZDs), and non-benzodiazepines or Z-drugs. These drugs work by suppressing central nervous system activity, and this suppression is dose-dependent. Older sedative medications, like barbiturates, follow a linear curve in...
2.2K
Parenteral Anesthetics: Overview01:24

Parenteral Anesthetics: Overview

995
Intravenous anesthetics are drugs administered parenterally to induce anesthesia or sedation. Propofol is a widely used agent formulated as a 1% emulsion in soybean oil, glycerol, and egg phosphatide. It induces rapid anesthesia primarily due to its rapid distribution from the bloodstream to target tissues and is metabolized in the liver. However, it can cause significant pain on injection and hypertriglyceridemia. Fospropofol, a water-based prodrug of propofol, lacks these adverse effects.
995
Stages of General Anesthesia01:22

Stages of General Anesthesia

2.5K
Various sedation levels offer significant advantages in facilitating procedural interventions for patients undergoing medical or invasive surgical procedures. These levels span from anxiolysis to general anesthesia, providing a spectrum of sedative effects to cater to specific patient needs. Anxiolysis reduces anxiety and is achieved through minimal sedation, enabling patients to remain awake and responsive while feeling more at ease during the procedure. This level can benefit minor...
2.5K
Sedatives and Hypnotics Drugs: Miscellaneous Agents01:17

Sedatives and Hypnotics Drugs: Miscellaneous Agents

957
Sedatives and hypnotics encompass a wide range of substances, each with its unique mechanism of action, uses, and potential adverse effects.
Melatonin congeners like ramelteon (Rozerem) and tasimelteon (Hetlioz) selectively bind to melatonin receptors (MT1 and MT2) and thus mimic the actions of melatonin, a hormone that regulates sleep-wake cycles. Tasimelteon is primarily used for non-24-hour sleep-wake disorder, common in blind patients. They are also used to treat conditions like insomnia...
957
Sedatives and Hypnotics Drugs: Barbiturates01:20

Sedatives and Hypnotics Drugs: Barbiturates

1.5K
Sedatives and hypnotics encompass a drug class that acts on the central nervous system (CNS) to alleviate anxiety, promote relaxation and induce sleep.These drugs function by amplifying the actions of the neurotransmitter γ-aminobutyric acid (GABA), resulting in reduced neuronal activity. Barbiturates, a subset of sedatives and hypnotics first synthesized in the late 1800s, are categorized into ultra-short, short, intermediate, and long-acting groups based on their duration of effect. A...
1.5K
Sedatives and Hypnotics Drugs: Benzodiazepines01:19

Sedatives and Hypnotics Drugs: Benzodiazepines

1.4K
Benzodiazepines have both sedative and hypnotic properties. They include compounds such as diazepam (Valium) and alprazolam (Xanax). Structurally, their cores are similar, consisting of the fusion of a benzene ring and a diazepine ring, but they share a common mechanism of action in the central nervous system (CNS).
Benzodiazepines work by enhancing the effects of the inhibitory neurotransmitter GABA. They bind to the GABAA receptor, increasing its affinity for GABA, which opens chloride...
1.4K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Clinician engagement shapes the impact of AI-based ECG screening for chronic liver disease in primary care.

NPJ digital medicine·2026
Same author

Influence of OSCAR-IB criteria on test-retest reliability of Spectralis SD-OCT retinal thickness measurements in people with Multiple Sclerosis.

Multiple sclerosis (Houndmills, Basingstoke, England)·2026
Same author

Milling-Induced Defects in Ni/Zirconia Catalysts for Enhancing Catalytic Activity in Dry Methane Reforming.

The journal of physical chemistry. C, Nanomaterials and interfaces·2026
Same author

Systematic review of terminology, definitions, and eligibility criteria in trials of neonatal encephalopathy, hypoxic-ischemic encephalopathy, and perinatal asphyxia.

Pediatric research·2026
Same author

GLP-1 receptor agonists in asthma: targeting metabolic-inflammatory crossroads.

Current opinion in pulmonary medicine·2026
Same author

Author Correction: Detection of undiagnosed liver cirrhosis via AI-enabled electrocardiogram: a pragmatic, cluster-randomized clinical trial.

Nature medicine·2026

Related Experiment Video

Updated: Apr 26, 2026

Drug-Induced Sleep Endoscopy DISE with Target Controlled Infusion TCI and Bispectral Analysis in Obstructive Sleep Apnea
07:54

Drug-Induced Sleep Endoscopy DISE with Target Controlled Infusion TCI and Bispectral Analysis in Obstructive Sleep Apnea

Published on: December 6, 2016

19.7K

Why is your patient sedated?

Olwen Murphy, Graham King, Ian Callanan

    International Journal of Health Care Quality Assurance
    |August 1, 2014
    PubMed
    Summary
    This summary is machine-generated.

    Clinical indication documentation for sedative/hypnotic (SH) medications is poor in hospitals. Most patients lack documented reasons for SH prescriptions, especially elderly, less mobile individuals, highlighting a need for better prescribing practices.

    More Related Videos

    Halogenated Agent Delivery in Porcine Model of Acute Respiratory Distress Syndrome via an Intensive Care Unit Type Device
    09:36

    Halogenated Agent Delivery in Porcine Model of Acute Respiratory Distress Syndrome via an Intensive Care Unit Type Device

    Published on: September 24, 2020

    2.5K
    Author Spotlight: A Non-Intubated Video-Assisted Thoracoscopic Surgery with Multimodal Analgesia and Sevoflurane Inhalation Anesthesia
    05:39

    Author Spotlight: A Non-Intubated Video-Assisted Thoracoscopic Surgery with Multimodal Analgesia and Sevoflurane Inhalation Anesthesia

    Published on: May 26, 2023

    2.7K

    Related Experiment Videos

    Last Updated: Apr 26, 2026

    Drug-Induced Sleep Endoscopy DISE with Target Controlled Infusion TCI and Bispectral Analysis in Obstructive Sleep Apnea
    07:54

    Drug-Induced Sleep Endoscopy DISE with Target Controlled Infusion TCI and Bispectral Analysis in Obstructive Sleep Apnea

    Published on: December 6, 2016

    19.7K
    Halogenated Agent Delivery in Porcine Model of Acute Respiratory Distress Syndrome via an Intensive Care Unit Type Device
    09:36

    Halogenated Agent Delivery in Porcine Model of Acute Respiratory Distress Syndrome via an Intensive Care Unit Type Device

    Published on: September 24, 2020

    2.5K
    Author Spotlight: A Non-Intubated Video-Assisted Thoracoscopic Surgery with Multimodal Analgesia and Sevoflurane Inhalation Anesthesia
    05:39

    Author Spotlight: A Non-Intubated Video-Assisted Thoracoscopic Surgery with Multimodal Analgesia and Sevoflurane Inhalation Anesthesia

    Published on: May 26, 2023

    2.7K

    Area of Science:

    • Pharmacology
    • Clinical Pharmacy
    • Patient Safety

    Background:

    • Sedative-hypnotic (SH) medications are frequently prescribed to hospital inpatients.
    • Ensuring appropriate use requires clear documentation of clinical indications.

    Purpose of the Study:

    • To evaluate the documentation of clinical indications for prescribed sedative-hypnotic (SH) medications.
    • To assess prescribing practices in a large, acute tertiary referral hospital.

    Main Methods:

    • An audit of 367 inpatient medication records for SH medications.
    • Review of medical and nursing notes to identify documented indications.

    Main Results:

    • SH medications were prescribed to 42.5% of inpatients.
    • Clinical indications were documented for only 24.4% of patients receiving SH medications.
    • Nurses prescribed most SH medications (74%), and documentation rates were low, particularly for elderly, less mobile patients (47% indication documented).

    Conclusions:

    • Significant shortcomings exist in documenting the clinical rationale for SH medication use.
    • Healthcare professionals, especially physicians, must improve justification of SH prescriptions in medical records.
    • Clear guidance is needed for high-risk patient groups to ensure safe and appropriate SH medication use.