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[A pathological study on herpes simplex virus infections in adults]
Summary
Herpes simplex virus (HSV) visceral organ infections occurred in 4% of autopsied cases, primarily affecting the esophagus and liver. HSV-1 antigen was detected in all cases, with co-infections common.
Area of Science:
- Pathology
- Virology
- Immunohistochemistry
Background:
- A retrospective pathological study examined 200 autopsied cases from 1981-1988.
- Investigated the incidence and characteristics of visceral herpes simplex virus (HSV) infections.
Observation:
- Eight patients (4.0%) presented with visceral HSV infections, and one additional case was diagnosed with HSV hepatitis.
- The affected individuals ranged from 34 to 70 years old, with a mean age of 58.
- Commonly involved organs included the esophagus (7/8), tongue (5/8), and liver (3/9).
Findings:
- Herpetic changes like ballooning degeneration and Cowdry type A inclusions were observed.
- Indirect immunoperoxidase staining confirmed HSV-1 antigen in all 9 cases.
- Concomitant infections with cytomegalovirus, aspergillus, candida, and bacteria were noted in several patients.
Implications:
- HSV can cause severe visceral organ disease, including fulminant hepatitis and interstitial pneumonia.
- The findings highlight the importance of considering HSV in autopsied cases with specific organ involvement.
- Co-infections with other pathogens may influence the clinical presentation and outcome of HSV infections.