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Updated: Apr 26, 2026
A Plasma Sample Preparation for Mass Spectrometry using an Automated Workstation
Published on: April 24, 2020
Biological sample preparation: attempts on productivity increasing in bioanalysis.
Somaieh Soltani1, Abolghasem Jouyban
1Drug Applied Research Center & Pharmacy Faculty, Tabriz University of Medical Sciences, Tabriz, Iran.
This review covers recent advancements in biological sample preparation for biomedical analysis. It evaluates various methods, including dilution, extraction, and novel techniques, for speed, reproducibility, and routine analysis suitability.
Area of Science:
- Biomedical Analysis
- Analytical Chemistry
Background:
- Sample preparation is a critical step in biomedical analysis.
- Efficient methods are needed to increase productivity and ensure reliable results.
Purpose of the Study:
- To review recent achievements in biological sample pretreatment.
- To evaluate methods based on productivity and suitability for routine analysis.
Main Methods:
- The review categorizes methods into dilution, filtration/dialysis, precipitation, extraction (SPE, LLE), novel techniques (TFC, IA, EME), and combined approaches.
- Each method's productivity and routine analysis suitability are assessed.
Main Results:
- Various sample preparation techniques offer different advantages in terms of speed and efficiency.
- Novel techniques and combined methods show promise for enhanced analytical workflows.
Conclusions:
- The choice of sample preparation method significantly impacts biomedical analysis outcomes.
- Further development in fast, reproducible techniques is crucial for advancing the field.
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