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Multistable switches and their role in cellular differentiation networks

Ahmadreza Ghaffarizadeh, Nicholas S Flann, Gregory J Podgorski

    BMC Bioinformatics
    |August 1, 2014
    PubMed
    Summary

    Biological multistable switches stabilize cell types during development. Adding two identical switches to gene regulatory networks significantly enhances cell type separation and directional transitions, shaping lineage trees.

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