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Related Experiment Video

Updated: Apr 26, 2026

Brain Imaging Investigation of the Neural Correlates of Emotional Autobiographical Recollection

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Published on: August 26, 2011

Baseline frontostriatal-limbic connectivity predicts reward-based memory formation.

Janne M Hamann¹, Eran Dayan, Friedhelm C Hummel

¹Human Cortical Physiology and Neurorehabilitation Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health, 10 Center Drive, Bethesda, Maryland, 20892; BrainImaging and NeuroStimulation (BINS) Laboratory, University Medical Center Hamburg-Eppendorf, Martinistrasse 52, 20251, Hamburg, Germany.

Human Brain Mapping

|August 1, 2014

Summary

Baseline brain connectivity in the frontostriatal-limbic network predicts how well individuals retain rewarded procedural skills long-term. This brain network

Keywords:

brain connectivity learning memory resting state functional magnetic resonance imaging reward learning ventral striatum

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Combined In Vivo Anatomical and Functional Tracing of Ventral Tegmental Area Glutamate Terminals in the Hippocampus

Combined In Vivo Anatomical and Functional Tracing of Ventral Tegmental Area Glutamate Terminals in the Hippocampus

Published on: September 9, 2020

Area of Science:

Neuroscience
Cognitive Science
Psychology

Background:

Reward significantly influences the learning and long-term memory of procedural skills.
Individual differences in learning from reward are substantial, but the underlying mechanisms remain unclear.

Purpose of the Study:

To investigate if baseline functional connectivity within the frontostriatal-limbic network can predict individual differences in rewarded learning.
To determine if this predictive relationship extends to long-term memory retention.

Main Methods:

Resting-state functional MRI was used to assess baseline functional connectivity in a frontostriatal-limbic network.
Two groups of participants (n=30 each) underwent visuomotor procedural learning with or without reward feedback.
Memory strength was evaluated immediately, 24 hours, and 1 month post-training.

Main Results:

Functional connectivity in the frontostriatal-limbic network predicted interindividual variability in rewarded learning, but not in unrewarded learning.
This predictive power was most pronounced for long-term memory retention.
No similar links were found in control networks (language and dorsal attention networks).

Conclusions:

Baseline functional connectivity within the frontostriatal-limbic network is a key predictor of long-term retention of rewarded procedural learning.
This finding highlights the role of intrinsic brain network organization in modulating reward-based learning.
The frontostriatal-limbic network's connectivity specifically supports memory consolidation in reward-associated learning contexts.