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Related Experiment Videos

Gastro retention using polymer cocoons.

Julien Arnold1, David Hunkeler

  • 1AQUA+ TECH Specialties , Geneva , Switzerland.

Artificial Cells, Nanomedicine, and Biotechnology
|August 1, 2014
PubMed
Summary

New gastro-retentive capsules, or "gastro cocoons," offer 24-hour stomach retention for controlled drug delivery. These durable capsules effectively deliver high drug payloads to the upper intestines.

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Area of Science:

  • Pharmaceutical Sciences
  • Materials Science

Background:

  • Controlled drug delivery systems are crucial for improving therapeutic efficacy.
  • Gastro-retentive drug delivery aims to prolong drug residence time in the stomach for enhanced absorption.

Purpose of the Study:

  • To develop and characterize novel gastro-retentive capsules for prolonged drug delivery.
  • To evaluate the retention, drug loading, mechanical strength, and release profile of the developed capsules.

Main Methods:

  • Preparation of gastro-retentive capsules using oppositely charged polyelectrolytes.
  • Assessment of capsule swelling, mechanical strength (compressive force), and X-ray visibility.
  • In vitro drug release studies using ambroxol hydrochloride as a model drug.

Main Results:

  • The developed capsules demonstrated 24-hour gastric retention.
  • Capsules exhibited high drug payload capacity (30%) and could swell to twice their initial volume.
  • The capsules possessed high mechanical strength, resisting 550 N of compressive force.
  • Linear, zero-order release kinetics were observed for ambroxol hydrochloride.

Conclusions:

  • The novel gastro-retentive capsules, termed "gastro cocoons," are a promising platform for controlled drug delivery.
  • These capsules offer enhanced gastric retention, high drug loading, and robust mechanical properties.
  • The observed zero-order release profile indicates predictable and sustained drug release into the upper intestines.
Keywords:
drug-deliveryencapsulationgastro-retentionpolyelectrolyte

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