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Core/shell Printing Scaffolds For Tissue Engineering Of Tubular Structures
Published on: September 27, 2019
Towards the Development of Smart 3D "gated scaffolds" for on-command delivery
Núria Mas1, Daniel Arcos, Lorena Polo
1Centro de Reconocimiento Molecular y Desarrollo Tecnológico (IDM), Unidad Mixta Universitat de València-Universitat Politècnica de València and Departamento de Química, Camino de Vera s/n, 46022, Valencia, Spain and CIBER de Bioingeniería, Biomateriales y Nanomedicina (CIBER-BBN), Spain.
Abstract:
A new approach towards the design of "gated scaffolds" based on the combination of capped mesoporous silica nanoparticles (MSNs) with porous biomaterials is reported. Using this approach, a 3D gelatin-based scaffold able to selectively deliver cargo in the presence of an APase enzyme is prepared and tested. This new design opens up the possibility of developing new smart biomaterials with advanced drug-delivery features.
