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Body surface dosimetry following re-injection of 111In-leucocytes

P J Mountford1, A J Coakley

  • 1Department of Nuclear Medicine, Kent and Canterbury Hospital, UK.

Nuclear Medicine Communications
|July 1, 1989
PubMed

Insights

Parents receiving indium-111 labelled white blood cells (111In-leucocytes) should limit activity to 10 MBq. This ensures close contact radiation doses to infants remain below 1 mSv, protecting child health.

Area of Science:

  • Nuclear Medicine
  • Medical Physics
  • Pediatric Radiation Safety

Background:

  • Indium-111 labelled white blood cells (111In-leucocytes) are used in diagnostic imaging.
  • Parental administration of 111In-leucocytes poses potential radiation exposure risks to infants.
  • Current UK guidelines recommend limiting contact for patients with residual activity exceeding 20 MBq.

Purpose of the Study:

  • To estimate radiation dose to infants from parents administered 111In-leucocytes.
  • To determine safe activity levels for 111In-leucocyte injections in parents of young infants.

Main Methods:

  • Thermoluminescent dosimeters were placed on the chest walls of eight patients.
  • Dose estimation was performed for infants in close contact with parents receiving 111In-leucocytes.
  • Radiation exposure was measured at five specific chest wall sites.

Main Results:

  • A 20 MBq injection of 111In-leucocytes to a parent resulted in a close contact dose exceeding 1 mSv for the infant.
  • Measured doses confirmed findings from a preliminary study.
  • The study established a correlation between injected activity and infant radiation exposure.

Conclusions:

  • The maximum recommended 111In-leucocyte activity for parents of young infants should be 10 MBq.
  • This dosage limit aims to keep infant radiation exposure below 1 mSv.
  • Adherence to this guideline enhances pediatric radiation safety during nuclear medicine procedures.

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