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Mixing Acid Salts and Layered Double Hydroxides in Nanoscale under Solid Condition
Hirokazu Nakayama1, Aki Hayashi2
1Department of Functional Molecular Chemistry, Kobe Pharmaceutical University, Kobe 658-8558, Japan. hiro@kobepharma-u.ac.jp.
Pharmaceutics
|August 1, 2014
Summary
Layered double hydroxides can immobilize potassium sorbate and aspartate under solid conditions, similar to aqueous solutions. This solid-state intercalation method offers a new way to encapsulate acidic drugs.
Area of Science:
- Materials Science
- Chemistry
Background:
- Layered double hydroxides (LDHs) are versatile materials with applications in drug delivery.
- Intercalation is a key process for incorporating molecules into LDH interlayers.
Purpose of the Study:
- To investigate the solid-state intercalation of sorbate and aspartate into layered double hydroxides.
- To compare the efficiency of solid-state intercalation with aqueous methods.
- To explore the potential of this method for acidic drug encapsulation.
Main Methods:
- Direct solid mixing of potassium sorbate, potassium aspartate, and sorbic acid with nitrate-type and chloride-type layered double hydroxides.
- Characterization of intercalation compounds to determine uptake and interlayer distances.
Main Results:
- Successful intercalation of sorbate and aspartate into nitrate-type LDH under solid conditions, achieving comparable uptakes to aqueous solutions.
- Sorbic acid did not intercalate under the tested solid conditions.
- Lower uptakes were observed when using chloride-type LDH compared to nitrate-type LDH.
- Solid-state intercalation demonstrated similar reactivity and extent to aqueous ion-exchange reactions.
Conclusions:
- Solid-state intercalation into layered double hydroxides is a viable method for immobilizing certain anionic compounds like sorbate and aspartate.
- Nitrate-type LDH shows higher efficiency for this solid-state process.
- This approach provides a simple, solvent-free method for nano-level encapsulation of acidic drugs within LDHs.
