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Related Experiment Video

Updated: Apr 26, 2026

Differentiation and Imaging of Brown Adipocytes from the Stromal Vascular Fraction of Interscapular Adipose Tissue from Newborn Mice
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Fat cells gain new identities.

Emmani B M Nascimento1, Mariëtte R Boon2, Wouter D van Marken Lichtenbelt3

  • 1Department of Human Biology, Maastricht University, P.O. Box 616; 6200MD Maastricht, the Netherlands.

Science Translational Medicine
|August 1, 2014
PubMed
Summary
This summary is machine-generated.

New cell-surface proteins ASC-1, PAT2, and P2RX5 can differentiate brown/beige from white adipocytes in mouse and human fat tissue. This finding aids in understanding adipose tissue subtypes.

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Area of Science:

  • Adipose tissue biology
  • Cell surface protein identification
  • Metabolic research

Background:

  • Brown and beige adipocytes are crucial for thermogenesis and energy expenditure.
  • Distinguishing between white and brown/beige adipocytes is important for metabolic research.
  • Novel markers for adipocyte subtypes are needed.

Purpose of the Study:

  • To identify novel cell-surface proteins that can distinguish between brown/beige and white adipocytes.
  • To investigate the potential of ASC-1, PAT2, and P2RX5 as markers for adipose tissue subtypes.

Main Methods:

  • Analysis of cell-surface protein expression in mouse and human adipose tissue.
  • Utilizing techniques to identify and validate novel protein markers.

Main Results:

  • ASC-1, PAT2, and P2RX5 were identified as newly discovered cell-surface proteins.
  • These proteins show potential in distinguishing brown/beige adipocytes from white adipocytes.
  • Validation was performed in both mouse and human adipose tissue samples.

Conclusions:

  • ASC-1, PAT2, and P2RX5 represent promising novel markers for brown/beige adipocytes.
  • These findings contribute to a better understanding of adipose tissue heterogeneity.
  • Further research can explore the functional roles of these proteins in adipocyte biology.