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On the 7-oxo-PGI2 induced late appearing long-lasting cytoprotective effect
L Szekeres1, Z Bálint, S Karcsu
1Institute of Pharmacology, Albert Szent-Györgyi Medical University, Szeged, Hungary.
Progress in Clinical and Biological Research
|January 1, 1989
Abstract:
Our results indicate that 7-oxo-PgI2 pretreatment may induce a long lasting cytoprotective effect by preventing ischemia induced intracellular potassium loss and sodium accumulation in myocardial cells of guinea pigs furthermore by protecting from ischemic ultrastructural changes as sarcomere shortening, mitochondrial swelling and irregularity of I, A and Z bands in the rabbit myocardium.