Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Drug Dependence01:17

Drug Dependence

1.9K
Medications are typically administered to achieve therapeutic effects. Some drugs can modify an individual's mood and perception, frequently resulting in various enjoyable experiences. However, this can result in drug dependency, a condition marked by continuous drug use despite potential negative consequences. Drug dependency primarily falls into two categories: psychological and physical dependence. Psychological dependence occurs when the pleasurable feelings induced by the drug...
1.9K
Drug Abuse and Addiction: Pharmacological Phenomena01:15

Drug Abuse and Addiction: Pharmacological Phenomena

1.6K
Drug dependence, abuse, and addiction are complex phenomena that can precipitate various abnormal states. Physical dependence refers to a state of pharmacological adaptation to a drug. This adaptation often results in tolerance—a reduced response to the drug after repeated administrations. When the drug use is abruptly stopped, withdrawal symptoms occur due to the body's need to readjust from the pharmacologically induced imbalance. However, tolerance and withdrawal symptoms do not...
1.6K
Substance Use Disorders Affecting Sleep01:24

Substance Use Disorders Affecting Sleep

605
Substance use disorders involve a pattern of using drugs more extensively than intended and continuing use despite harmful consequences. This includes legal substances like alcohol and nicotine, as well as illegal drugs. These disorders often involve both physical and psychological dependence, reflecting compulsive use of substances that significantly alter thoughts, feelings, and behaviors, contributing to a major public health issue.
Understanding the concepts of physical dependence,...
605
Dosage Regimen: Individualization01:24

Dosage Regimen: Individualization

387
Individualization in dosing regimens is the customization of medication doses for individual patients. Its necessity arises from the goal of maximizing therapeutic benefits while minimizing risks. This approach is pivotal because human responses to drugs can vary widely; what is effective for one person may be inadequate or excessive for another. Interpatient (intersubject) variability refers to differences in drug responses between individuals, while intrapatient (intrasubject) variability...
387
Drug Accumulation During Multiple Dosing: Repetitive IV Injections01:21

Drug Accumulation During Multiple Dosing: Repetitive IV Injections

525
Calculating drug dosage and accumulation in multiple-dose regimens is crucial for achieving therapeutic efficacy while avoiding toxicity. This involves determining the plasma drug concentrations over time to optimize dosing schedules. The principle of superposition is fundamental in this process, allowing for the prediction of drug concentration in plasma following multiple doses based on single-dose data.The principle of superposition asserts that the plasma concentration-time curves from...
525
Therapeutic Drug Monitoring: Affecting Factors01:29

Therapeutic Drug Monitoring: Affecting Factors

428
Therapeutic Drug Monitoring (TDM) is the clinical practice of measuring specific drug levels in a patient's blood or body tissues to manage and optimize therapy. TDM is crucial for drugs with narrow therapeutic windows, like warfarin and phenytoin, where incorrect doses can lead to treatment failure or severe side effects. This monitoring ensures the dosage administered is within a safe and effective range. The factors affecting therapeutic drug monitoring include:Patient-Specific Factors:a.
428

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

A process-oriented functional capacity assessment: First application of the neuropsychological evaluation of the UPSA (NEUPSA).

Applied neuropsychology. Adult·2026
Same author

THC induced similar physiological effects on HIV transgenic rats and their controls without affecting HIV-induced deficits in effortful motivation.

Journal of cannabis research·2026
Same author

Quantifying Exploratory Behavior In The Human Behavioral Pattern Monitor Using Automated Video Tracking.

Methods in Psychology (Online)·2025
Same author

Chronic cannabis use in people with bipolar disorder is associated with comparable decision-making and functional outcome to healthy participants.

Translational psychiatry·2025
Same author

Heart rate variability in unstably housed Veterans with mental health conditions.

Journal of clinical and experimental neuropsychology·2025
Same author

Beneficial and adverse effects of THC on cognition in the HIV-1 transgenic rat model: Importance of exploring task- and sex-dependent outcomes.

Brain, behavior, and immunity·2025

Related Experiment Video

Updated: Apr 26, 2026

A General Method for Evaluating Deep Brain Stimulation Effects on Intravenous Methamphetamine Self-Administration
09:16

A General Method for Evaluating Deep Brain Stimulation Effects on Intravenous Methamphetamine Self-Administration

Published on: January 22, 2016

17.6K

Elevated intraindividual variability in methamphetamine dependence is associated with poorer everyday functioning.

Erin E Morgan1, Katie L Doyle2, Arpi Minassian1

  • 1Department of Psychiatry, University of California-San Diego, La Jolla, CA, USA.

Psychiatry Research
|August 2, 2014
PubMed
Summary

Methamphetamine dependence elevates neurocognitive intraindividual variability (IIV), indicating cognitive dyscontrol. This heightened IIV in methamphetamine users is linked to poorer daily functioning and real-world problems.

Keywords:
Activities of daily livingCognitive controlNeuropsychological assessmentSubstance dependenceWithin-person variability

More Related Videos

Microdialysis of Ethanol During Operant Ethanol Self-administration and Ethanol Determination by Gas Chromatography
10:11

Microdialysis of Ethanol During Operant Ethanol Self-administration and Ethanol Determination by Gas Chromatography

Published on: September 5, 2012

19.1K
A Protocol for Measuring Cue Reactivity in a Rat Model of Cocaine Use Disorder
07:51

A Protocol for Measuring Cue Reactivity in a Rat Model of Cocaine Use Disorder

Published on: June 18, 2018

10.2K

Related Experiment Videos

Last Updated: Apr 26, 2026

A General Method for Evaluating Deep Brain Stimulation Effects on Intravenous Methamphetamine Self-Administration
09:16

A General Method for Evaluating Deep Brain Stimulation Effects on Intravenous Methamphetamine Self-Administration

Published on: January 22, 2016

17.6K
Microdialysis of Ethanol During Operant Ethanol Self-administration and Ethanol Determination by Gas Chromatography
10:11

Microdialysis of Ethanol During Operant Ethanol Self-administration and Ethanol Determination by Gas Chromatography

Published on: September 5, 2012

19.1K
A Protocol for Measuring Cue Reactivity in a Rat Model of Cocaine Use Disorder
07:51

A Protocol for Measuring Cue Reactivity in a Rat Model of Cocaine Use Disorder

Published on: June 18, 2018

10.2K

Area of Science:

  • Neuroscience
  • Psychology
  • Addiction Research

Background:

  • Methamphetamine dependence is linked to executive dysfunction.
  • Neurocognitive intraindividual variability (IIV) reflects cognitive dyscontrol and predicts daily functioning issues.
  • No prior studies have investigated IIV in methamphetamine dependence.

Purpose of the Study:

  • To examine neurocognitive intraindividual variability (IIV) in methamphetamine-dependent individuals.
  • To determine the relationship between IIV and daily functioning in this population.

Main Methods:

  • A vigilance task was administered to 35 methamphetamine-dependent (MA+) and 55 non-using (MA-) participants.
  • A mixed model ANOVA controlled for covariates including education, mean reaction time, global cognitive performance, and HIV status.
  • Neuropsychological and performance-based measures of everyday functioning were assessed.

Main Results:

  • Methamphetamine-dependent individuals exhibited significantly elevated IIV compared to controls.
  • Elevated IIV was consistent across all blocks of the vigilance task.
  • Within the MA group, higher IIV correlated with executive dysfunction, slower reaction times, recent MA use, poorer driving simulation performance, impaired functional skills, and increased cognitive complaints.

Conclusions:

  • Methamphetamine users show increased neurocognitive intraindividual variability (IIV), suggesting cognitive dyscontrol.
  • Elevated IIV in MA users is associated with deficits in executive function and psychomotor speed.
  • This cognitive dyscontrol may contribute to the real-world functional impairments observed in methamphetamine dependence.