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Lithium increases 5-HT-mediated neuroendocrine responses in tricyclic resistant depression
P J Cowen1, S L McCance, P R Cohen
1MRC Unit of Clinical Pharmacology, Littlemore Hospital, Oxford, UK.
Psychopharmacology
|January 1, 1989
Abstract:
The addition of lithium to the tricyclic antidepressant medication of 11 depressed patients resulted in an increase in the prolactin response to L-tryptophan after both 4 days and 4 weeks of lithium treatment. There was also a significant fall in Hamilton Depression scores. The results suggest that lithium and tricyclic antidepressants may act synergistically to enhance certain aspects of brain 5-HT function in depressed patients.