Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Tension Response at Adherens Junctions01:26

Tension Response at Adherens Junctions

3.1K
The adherens junctions that anchor cells together are multi-protein complexes that dynamically adapt to mechanical stimuli such as tensile forces and shear stress. Mechanosensory proteins in these junctions can sense such mechanical stimuli and undergo a shift in their conformation, resulting in an altered function — a process called mechanotransduction.
α-Catenin as a Mechanosensory Protein
The α-catenin of adherens junctions is an allosteric protein with three VH (vinculin...
3.1K
Cadherins in Tissue Organization01:19

Cadherins in Tissue Organization

3.5K
The cadherins are a superfamily of cell adhesion molecules comprising over 180 variants, with specific tissues expressing a particular combination of cadherin types. Cadherins generally exhibit homophilic binding; i.e., cadherins on one cell bind to cadherins of the same or closely related type on another cell. Thus, cells of the same type have a specific affinity to bind to each other and sort themselves into clusters to form tissues.
Cell Sorting During Development
Cell sorting plays an...
3.5K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

PES-8 is required for Cytoskeletal Organization and Contractility in the <i>C. elegans</i> Spermatheca.

bioRxiv : the preprint server for biology·2026
Same author

Stage-specific transcriptomics of a leader cell reveals cell machineries driving collective invasion.

The Journal of cell biology·2026
Same author

A switch in collagen expression regulates cessation of distal tip cell migration in C. elegans.

Matrix biology : journal of the International Society for Matrix Biology·2026
Same author

GOA-1 regulates spermathecal transits.

microPublication biology·2025
Same author

A switch in collagen expression regulates cessation of distal tip cell migration in <i>C. elegans</i>.

bioRxiv : the preprint server for biology·2025
Same author

On-demand delivery of fibulin-1 protects the basement membrane during cyclic stretching in C. elegans.

Developmental cell·2025

Related Experiment Video

Updated: Apr 26, 2026

Using a Microfluidics Device for Mechanical Stimulation and High Resolution Imaging of C. elegans
10:39

Using a Microfluidics Device for Mechanical Stimulation and High Resolution Imaging of C. elegans

Published on: February 19, 2018

10.0K

Mechanotransduction in C. elegans morphogenesis and tissue function.

Erin J Cram1

  • 1Department of Biology, Northeastern University, Boston, Massachusetts, USA.

Progress in Molecular Biology and Translational Science
|August 2, 2014
PubMed
Summary
This summary is machine-generated.

Mechanobiology explores how cells sense physical cues, influencing stem cell differentiation and cancer metastasis. Research in *Caenorhabditis elegans* advances understanding of how cells convert mechanical forces into biochemical signals for tissue function.

Keywords:
C. elegansDevelopmentImaging toolsMechanical forcesMorphogenesis

More Related Videos

Visualizing Neuroblast Cytokinesis During C. elegans Embryogenesis
09:52

Visualizing Neuroblast Cytokinesis During C. elegans Embryogenesis

Published on: March 12, 2014

11.3K
Calcium Imaging in Freely Behaving Caenorhabditis elegans with Well-Controlled, Nonlocalized Vibration
06:50

Calcium Imaging in Freely Behaving Caenorhabditis elegans with Well-Controlled, Nonlocalized Vibration

Published on: April 29, 2021

2.5K

Related Experiment Videos

Last Updated: Apr 26, 2026

Using a Microfluidics Device for Mechanical Stimulation and High Resolution Imaging of C. elegans
10:39

Using a Microfluidics Device for Mechanical Stimulation and High Resolution Imaging of C. elegans

Published on: February 19, 2018

10.0K
Visualizing Neuroblast Cytokinesis During C. elegans Embryogenesis
09:52

Visualizing Neuroblast Cytokinesis During C. elegans Embryogenesis

Published on: March 12, 2014

11.3K
Calcium Imaging in Freely Behaving Caenorhabditis elegans with Well-Controlled, Nonlocalized Vibration
06:50

Calcium Imaging in Freely Behaving Caenorhabditis elegans with Well-Controlled, Nonlocalized Vibration

Published on: April 29, 2021

2.5K

Area of Science:

  • Mechanobiology
  • Cellular Mechanotransduction
  • Biophysics

Background:

  • Emerging field investigating cellular responses to physical environments.
  • Cell stiffness influences stem cell differentiation and cancer metastasis.
  • Understanding mechanotransduction is crucial for tissue function.

Purpose of the Study:

  • Summarize recent insights into mechanical forces in morphogenesis and tissue function.
  • Highlight contributions of *Caenorhabditis elegans* research.
  • Explore mechanical regulation across multiple biological scales.

Main Methods:

  • Review of current literature on mechanobiology.
  • Focus on *Caenorhabditis elegans* as a model organism.
  • In vivo quantitative bioimaging and gene discovery platforms.

Main Results:

  • Mechanical forces play a significant role in cell differentiation and tissue development.
  • Mechanotransduction pathways convert physical cues into biochemical signals.
  • *C. elegans* models reveal in vivo mechanisms of mechanical regulation.

Conclusions:

  • Mechanobiology is key to understanding fundamental biological processes.
  • The *C. elegans* system is a powerful tool for mechanobiology research.
  • Further research will elucidate complex mechanical signaling in tissues.