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The tumour-induced systemic environment as a critical regulator of cancer progression and metastasis
Sandra S McAllister1, Robert A Weinberg2
1Hematology Division, Brigham and Women's Hospital, and Department of Medicine, Harvard Medical School, Boston, Massachusetts, 02115, USA; the Broad Institute of Harvard and MIT, Cambridge, Massachusetts, 02142, USA; and the Harvard Stem Cell Institute, Cambridge, Massachusetts, 02138, USA.
Abstract:
Recent pre-clinical and clinical research has provided evidence that cancer progression is driven not only by a tumour's underlying genetic alterations and paracrine interactions within the tumour microenvironment, but also by complex systemic processes. We review these emerging paradigms of cancer pathophysiology and discuss how a clearer understanding of systemic regulation of cancer progression could guide development of new therapeutic modalities and efforts to prevent disease relapse following initial diagnosis and treatment.
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