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Related Experiment Video

Updated: Apr 26, 2026

Establishing a Porcine Ex Vivo Cornea Model for Studying Drug Treatments against Bacterial Keratitis

Establishing a Porcine Ex Vivo Cornea Model for Studying Drug Treatments against Bacterial Keratitis

Published on: May 12, 2020

Severe Staphylococcus lugdunensis keratitis.

N Inada¹, N Harada, M Nakashima

¹Division of Ophthalmology, Department of Visual Sciences, Nihon University School of Medicine, 30-1 Oyaguchi-Kamichou, Itabashi-ku, Tokyo, 173-8610, Japan, inada.noriko@nihon-u.ac.jp.

|August 2, 2014

Summary

This summary is machine-generated.

A severe case of Staphylococcus lugdunensis keratitis, a rare cause of bacterial eye infection, led to corneal perforation. Prompt identification and tailored antibiotic therapy are crucial for managing such sight-threatening conditions.

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Area of Science:

Ophthalmology
Infectious Diseases
Microbiology

Background:

Suppurative keratitis is a serious eye infection often caused by common bacteria.
Early diagnosis and empiric treatment are vital for preventing vision loss.

Observation:

A 77-year-old woman presented with severe suppurative keratitis and a corneal abscess in her right eye.
Bacterial culture identified Staphylococcus lugdunensis as the causative agent.
The patient experienced corneal perforation despite initial empiric antibiotic therapy.

Findings:

Staphylococcus lugdunensis, a less common cause of keratitis, can lead to severe outcomes.
Initial empiric antibiotics showed sensitivity but high minimum inhibitory concentrations (MICs) for S. lugdunensis.
Treatment was adjusted to levofloxacin ophthalmic solution, resulting in healing with a corneal scar.

Implications:

This case highlights the importance of considering rare pathogens in severe keratitis.
Accurate microbial identification and antibiotic susceptibility testing are critical for effective treatment planning.
Tailoring therapy based on detailed microbiological analysis can improve outcomes in complex infectious keratitis cases.