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Tumor Immunotherapy

Tumor Immunotherapy

Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.

Cell-mediated Immune Responses

Cell-mediated Immune Responses

Cancer Vaccines

Cancer Vaccines

Cancer treatment vaccines are a rapidly evolving field that offers a promising approach to immunotherapy. Unlike traditional vaccines that prevent diseases, cancer treatment vaccines are designed to treat existing cancers by stimulating the immune system to recognize and attack cancer cells.
Cancer vaccines come in two categories: preventive (prophylactic) and treatment (active). Preventive vaccines, such as the Human Papillomavirus (HPV) vaccine, protect against viruses that cause certain...

Combination Therapies and Personalized Medicine

Combination Therapies and Personalized Medicine

Combining two or more treatment methods increases the life span of cancer patients while reducing damage to vital organs or tissue from the overuse of a single treatment. Combination therapy also targets different cancer-inducing pathways, thus reducing the chances of developing resistance to treatment.
The combination of the drug acetazolamide and sulforaphane is a good example of combination therapy to treat cancer. The cells in the interior of a large tumor often die due to the hypoxic and...

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Related Experiment Video

Updated: Apr 26, 2026

Automated Cell Enrichment of Cytomegalovirus-specific T cells for Clinical Applications using the Cytokine-capture System

Automated Cell Enrichment of Cytomegalovirus-specific T cells for Clinical Applications using the Cytokine-capture System

Published on: October 5, 2015

Cellular immunotherapy for pediatric solid tumors.

Meenakshi Hegde¹, Alexander J Moll², Tiara T Byrd³

¹Center for Cell and Gene Therapy, Baylor College of Medicine, Houston, Texas, USA; Texas Children's Cancer Center, Baylor College of Medicine, Houston, Texas, USA; Department of Pediatrics, Baylor College of Medicine, Houston, Texas, USA.

|August 2, 2014

Summary

This summary is machine-generated.

Novel cell-based immunotherapies show promise for treating pediatric solid tumors, offering new hope for high-risk patients. Research is ongoing to overcome challenges and expand these advanced treatments.

Keywords:

T cell cell therapy pediatric solid tumor vaccine

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Published on: February 1, 2013

Area of Science:

Pediatric Oncology
Immunotherapy
Tumor Biology

Background:

Despite advances, pediatric solid tumors with metastatic or recurrent disease have poor outcomes with conventional therapies.
Understanding tumor biology and immune interactions is crucial for developing new treatments.
Novel immune-based therapies offer alternative options for high-risk pediatric malignancies.

Purpose of the Study:

To review current early-phase cell-based immunotherapy efforts for pediatric solid tumors.
To discuss the rationale behind these novel therapeutic approaches.
To identify and discuss the challenges associated with pediatric immunotherapy.

Main Methods:

Review of contemporary early-phase clinical trials.
Analysis of safety and anti-tumor efficacy data for cell-based therapies.
Exploration of tumor vaccines and adoptive cell transfer strategies.

Main Results:

Cellular immunotherapies have demonstrated good tolerability in early clinical trials.
Promising clinical responses have been observed in some pediatric solid tumors.
Knowledge regarding immunotherapy for pediatric tumors remains limited.

Conclusions:

Cell-based immunotherapy represents a promising frontier for pediatric solid tumors.
Further research is needed to overcome challenges and expand the application of these therapies.
Early clinical trials indicate potential for improved outcomes in high-risk pediatric cancer patients.