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Related Experiment Video

Updated: Apr 26, 2026

Induction of Paralysis and Visual System Injury in Mice by T Cells Specific for Neuromyelitis Optica Autoantigen Aquaporin-4

Induction of Paralysis and Visual System Injury in Mice by T Cells Specific for Neuromyelitis Optica Autoantigen Aquaporin-4

Published on: August 21, 2017

Neuromyelitis optica: a diffusional kurtosis imaging study.

T M Doring¹, F C R Lopes², T T A Kubo³

¹From the Universidade Federal Rio de Janeiro (T.M.D., F.C.R.L., G.T., E.L.G.), Rio de Janeiro, Brazil Clínica de Diagnóstico Por Imagem and Multi-imagem (T.M.D., F.C.R.L., T.T.A.K., G.T., M.C.K., R.C.D., E.L.G.), Diagnósticos da América, Rio de Janeiro, Brazil thomas.doring@gmail.com.

AJNR. American Journal of Neuroradiology

|August 2, 2014

Summary

This summary is machine-generated.

Diffusional kurtosis imaging detects white matter changes in neuromyelitis optica patients. This advanced MRI technique reveals subtle alterations in normal-appearing white matter, offering new insights into the disease.

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Area of Science:

Neuroimaging
Radiology
Neurology

Background:

Neuromyelitis optica (NMO) often shows normal brain MRI or lesions in specific areas.
Conventional MRI may not detect subtle white matter changes in NMO.

Purpose of the Study:

To evaluate diffusional kurtosis imaging (DKI) for detecting alterations in normal-appearing white matter in NMO patients.
To explore the relationship between DKI and conventional diffusion tensor imaging (DTI) parameters in NMO.

Main Methods:

13 NMO patients and 13 controls underwent brain MRI with conventional and DKI sequences.
Tract-based spatial statistics and region-of-interest analyses were used to compare DKI and DTI parameters.
Correlations were performed to assess the relationship between DKI and DTI parameters.

Main Results:

Several DKI and DTI parameters were altered in NMO patients' white matter compared to controls.
A significant decrease in radial kurtosis was observed in specific white matter tracts.
Negative correlations were found between DKI parameters (kurtosis) and DTI parameters (diffusivity), and positive correlations with fractional anisotropy.

Conclusions:

DKI reveals differences in diffusion and kurtosis parameters, particularly radial kurtosis, in the normal-appearing white matter of NMO patients.
These findings suggest DKI may be a sensitive tool for detecting NMO-related white matter changes.
Larger studies are needed to confirm the clinical impact of these advanced neuroimaging findings.