Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Transcription Factors02:16

Transcription Factors

70.5K
Tissue-specific transcription factors contribute to diverse cellular functions in mammals. For example, the gene for beta globin, a major component of hemoglobin, is present in all cells of the body. However, it is only expressed in red blood cells because the transcription factors that can bind to the promoter sequences of the beta globin gene are only expressed in these cells. Tissue-specific transcription factors also ensure that mutations in these factors may impair only the function of...
70.5K
Transcription Factors02:16

Transcription Factors

21.4K
21.4K
Master Transcription Regulators02:23

Master Transcription Regulators

6.0K
Master transcription regulators are regulatory proteins that are predominantly responsible for regulating the expression of multiple genes. Often these genes work in concert to drive a  complex process. Activation of a master transcription regulator can lead to a cascade of transcriptional activation necessary for that outcome. These regulators can directly bind to the regulatory sequences of the various genes involved, or they can indirectly regulate transcription by binding to regulatory...
6.0K
Master Transcription Regulators02:23

Master Transcription Regulators

1.8K
1.8K
General Transcription Factors01:30

General Transcription Factors

5.9K
Tissue-specific transcription factors contribute to diverse cellular functions in mammals. For example, the gene for beta globin, a major component of hemoglobin, is present in all cells of the body. However, it is only expressed in red blood cells because the transcription factors that can bind to the promoter sequences of the beta globin gene are only expressed in these cells. Tissue-specific transcription factors also ensure that mutations in these factors may impair only the function of...
5.9K
RNA Polymerase II Accessory Proteins02:36

RNA Polymerase II Accessory Proteins

8.9K
Proteins that regulate transcription can do so either via direct contact with RNA Polymerase or through indirect interactions facilitated by adaptors, mediators, histone-modifying proteins, and nucleosome remodelers. Direct interactions to activate transcription is seen in bacteria as well as in some eukaryotic genes. In these cases, upstream activation sequences are adjacent to the promoters, and the activator proteins interact directly with the transcriptional machinery. For example, in...
8.9K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Distinct prokaryotic gut microbiome and proviral-immune axes of pathophysiology in Sickle Cell Disease.

bioRxiv : the preprint server for biology·2026
Same author

A new advance in therapeutic induction of fetal hemoglobin on an uncertain road to durable access.

Molecular therapy : the journal of the American Society of Gene Therapy·2025
Same author

STING and VDAC inhibitors attenuate inflammation and ineffective erythropoiesis caused by an altered metabolome in the <i>Nan</i> (EKLF/E339D) mouse model of neonatal anemia.

bioRxiv : the preprint server for biology·2025
Same author

International variations in body mass index within the CASiRe global cohort of sickle cell disease patients.

Journal of sickle cell disease·2025
Same author

National Alliance of Sickle Cell Centers Consensus Recommendations on Sickle Cell Disease Health Maintenance: A Consensus Statement.

JAMA network open·2025
Same author

Higher aged neutrophils and differential inflammatory profiles in sickle cell disease patients on chronic transfusion therapy versus those on hydroxyurea.

Frontiers in immunology·2025

Related Experiment Video

Updated: Apr 26, 2026

A Chromatin Immunoprecipitation Assay to Identify Novel NFAT2 Target Genes in Chronic Lymphocytic Leukemia
09:52

A Chromatin Immunoprecipitation Assay to Identify Novel NFAT2 Target Genes in Chronic Lymphocytic Leukemia

Published on: December 4, 2018

7.2K

KLF1: when less is more.

Deepa Manwani1, James J Bieker2

  • 1ALBERT EINSTEIN COLLEGE OF MEDICINE.

Blood
|August 2, 2014
PubMed
Summary
This summary is machine-generated.

Mutations in Krüppel-like factor-1 (KLF1) are common in beta-thalassemia patients, leading to milder symptoms. This finding highlights KLF1

More Related Videos

A Rapid In Vivo Bioassay for Developmentally Active Enhancers
00:08

A Rapid In Vivo Bioassay for Developmentally Active Enhancers

1.1K
Investigating Interactions Between Histone Modifying Enzymes and Transcription Factors in vivo by Fluorescence Resonance Energy Transfer
11:33

Investigating Interactions Between Histone Modifying Enzymes and Transcription Factors in vivo by Fluorescence Resonance Energy Transfer

Published on: October 14, 2022

1.9K

Related Experiment Videos

Last Updated: Apr 26, 2026

A Chromatin Immunoprecipitation Assay to Identify Novel NFAT2 Target Genes in Chronic Lymphocytic Leukemia
09:52

A Chromatin Immunoprecipitation Assay to Identify Novel NFAT2 Target Genes in Chronic Lymphocytic Leukemia

Published on: December 4, 2018

7.2K
A Rapid In Vivo Bioassay for Developmentally Active Enhancers
00:08

A Rapid In Vivo Bioassay for Developmentally Active Enhancers

1.1K
Investigating Interactions Between Histone Modifying Enzymes and Transcription Factors in vivo by Fluorescence Resonance Energy Transfer
11:33

Investigating Interactions Between Histone Modifying Enzymes and Transcription Factors in vivo by Fluorescence Resonance Energy Transfer

Published on: October 14, 2022

1.9K

Area of Science:

  • Hematology
  • Genetics
  • Molecular Biology

Background:

  • Hemoglobinopathies, such as beta-thalassemia, exhibit significant phenotypic variability.
  • The genetic factors influencing this variability are not fully understood.

Purpose of the Study:

  • To investigate the prevalence and impact of Krüppel-like factor-1 (KLF1) mutations in patients with beta-thalassemia.
  • To understand the role of KLF1 in modulating the phenotype of hemoglobinopathies.

Main Methods:

  • Analysis of patient data to determine the prevalence of KLF1 mutations.
  • Correlation of KLF1 mutation status with clinical phenotypes in beta-thalassemia patients.

Main Results:

  • Mutations in KLF1 were found to be more prevalent in beta-thalassemia patients than previously recognized.
  • KLF1 mutations were associated with a milder clinical phenotype in these patients.

Conclusions:

  • Monoallelic KLF1 mutations can modulate the phenotype of hemoglobinopathies.
  • KLF1 is an important factor contributing to the variability observed in beta-thalassemia.