Related Experiment Video
Updated: Apr 26, 2026

Perturbations of Circulating miRNAs in Irritable Bowel Syndrome Detected Using a Multiplexed High-throughput Gene Expression Platform
Published on: November 30, 2016
Irritable bowel syndrome and food interaction
Rosario Cuomo1, Paolo Andreozzi1, Francesco Paolo Zito1
1Rosario Cuomo, Paolo Andreozzi, Francesco Paolo Zito, Valentina Passananti, Giovanni De Carlo, Giovanni Sarnelli, Department Of Clinical Medicine and Surgery, Federico II University Hospital, School of Medicine, 80131 Naples, Italy.
Dietary changes can significantly improve symptoms for individuals with Irritable Bowel Syndrome (IBS). Restricting fermentable carbohydrates and sugar alcohols offers relief, highlighting diet
Area of Science:
- Gastroenterology
- Dietary Science
- Microbiome Research
Background:
- Irritable bowel syndrome (IBS) is a prevalent gastrointestinal disorder with often unsatisfactory therapeutic outcomes.
- Factors implicated in IBS pathogenesis include motility issues, altered gut permeability, microbiome changes, and brain-gut axis dysfunction.
- Food intake frequently triggers or exacerbates IBS symptoms, indicating a critical role for diet.
Purpose of the Study:
- To review current evidence on the impact of diet on IBS symptoms.
- To highlight the significance of dietary interventions in managing IBS.
Main Methods:
- Literature review summarizing recent research on diet and IBS.
- Analysis of studies investigating the effects of specific dietary components on IBS symptomology.
Main Results:
- A diet low in fermentable, poorly absorbed carbohydrates and sugar alcohols demonstrates beneficial effects on IBS symptoms.
- Dietary strategies are emerging as a key component in the management of IBS.
Conclusions:
- Diet plays a crucial role in the management of Irritable Bowel Syndrome.
- Further research is necessary to fully elucidate the food-IBS relationship.
- Dietary interventions, particularly carbohydrate restriction, are expected to be central to future IBS therapeutic strategies.
Related Concept Videos
Irritable Bowel Syndrome I: Introduction
IBS is a chronic condition that can persist over a long period or recur frequently.
The pathogenesis of IBS involves a complex interplay of the following factors:
Altered...
Irritable Bowel Syndrome
Irritable Bowel Syndrome II: Clinical Features and Diagnostic Evaluation
Irritable Bowel Syndrome (IBS) is classified into subtypes based on the predominant bowel habits as determined by the Bristol Stool Form Scale (BSFS). The subtypes are:
Chronic Bowel Disorders: Introduction
Irritable Bowel Syndrome (IBS) is a common disorder affecting the gastrointestinal tract. The distinctive feature is recurrent abdominal pain associated with altered bowel movements, manifesting as constipation, diarrhea, or fluctuating between both. The...
Inflammatory Bowel Disease III: Diagnostic Studies and Management I-Nutritional Therapy
Diagnostic studies
A colonoscopy is the definitive screening test, distinguishing ulcerative colitis from other colon diseases with similar symptoms. During a colonoscopy test, inflamed mucosa with exudate ulcerations can be observed, and biopsies are taken to determine the histologic characteristics of the...
Irritable Bowel Syndrome III: Medical and Nursing Management

