Related Experiment Video
Updated: Apr 26, 2026
Laparoscopic Splenectomy with Pericardial Devascularization for Hypersplenism and Esophageal Variceal Hemorrhage Due to Portal Hypertension
Published on: November 15, 2024
Perioperative advantages of modified laparoscopic vs open splenectomy and azygoportal disconnection
Guo-Qing Jiang1, Ping Chen1, Jian-Jun Qian1
1Guo-Qing Jiang, Ping Chen, Jian-Jun Qian, Jie Yao, Xiao-Dong Wang, Sheng-Jie Jin, Dou-Sheng Bai, Department of Hepatobiliary Surgery, Clinical Medical College of Yangzhou University, Yangzhou 225001, Jiangsu Province, China.
Aim:
To investigate perioperative outcomes in patients undergoing modified laparoscopic splenectomy or open splenectomy and azygoportal disconnection for portal hypertension.
Methods:
This study included 44 patients who underwent modified laparoscopic splenectomy and azygoportal disconnection (MLSD) and 71 who underwent open procedures for portal hypertension. Blood samples were collected before surgery and on days 1, 3, and 7 after surgery. Markers of liver and renal function, C-reactive protein (CRP), interleukin-6 (IL-6), and procalcitonin (PCT) were measured, and perioperative variables were compared between the two groups.
Results:
The modified laparoscopic group showed significantly better and faster recovery, better liver and renal function, and fewer complications than the open group. CRP, IL-6, and PCT concentrations on postoperative days 1, 3, and 7 were significantly lower in the modified laparoscopic group than in the open group.
Conclusion:
MLSD was associated with lower inflammatory immune responses, less impairment of liver and renal function, and faster and better recovery.
