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Tertiary lymphoid tissue: A gateway for T cells in the tumor microenvironment
Giuseppe Di Caro1, Federica Marchesi2
1Department of Immunology and Inflammation; Humanitas Clinical and Research Center; Rozzano, Italy.
Abstract:
Tumor-infiltrating lymphocytes influence colorectal cancer progression. We have recently documented that tertiary lymphoid tissue in the colorectal cancer microenvironment orchestrates lymphocyte infiltration and that tertiary lymphoid tissue and lymphocytes cooperate in a coordinated antitumor immune response to improve patient outcome. Thus, tertiary lymphoid tissue represents a potential target in the design of tailored immune-based therapeutic approaches.
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