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In Vivo Inhibition of MicroRNA to Decrease Tumor Growth in Mice
Published on: August 23, 2019
The role of noncoding RNA in thyroid cancer
1Department of General Surgery, Xiangya Hospital, Central South University, Xiangya Road 87, Changsha 410008, People's Republic of China.
Abstract:
Increasing noncoding RNAs (ncRNAs) were found to show abnormal expression patterns in various human cancers. Based on size, ncRNAs are generally grouped into two categories, short noncoding RNAs and long noncoding RNAs (lncRNAs) of greater than 200 nt. Small noncoding RNAs include microRNAs, piRNAs, snoRNAs, and endogenous siRNAs, out of the role of miRNAs in development and cancer biology has been extensively studied. In contrast to small noncoding RNAs like miRNAs, long noncoding RNAs are much less known concerning their functions in human cancers especially in thyroid cancer. The present review highlighted the roles of miRNAs and newly discovered lncRNAs in thyroid development, tumorigenesis, metastasis, and their clinical implication.
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