A lipophilic "fully-anti" dodecamer from a (5'S)-5',8-cyclo-2'-deoxyguanosine
Silvia Pieraccini1, Michael A Terzidis, Enrico J Baldassarri
1Dipartimento di Chimica 'Giacomo Ciamician' Alma Mater Studiorum - Università di Bologna, via San Giacomo 11, 40126 Bologna, Italy. stefano.masiero@unibo.it.
Abstract:
The self-assembly of a lipophilic derivative of (5'S)-5',8-cyclo-2'-deoxyguanosine, a mutagenic product formed by hydroxyl radical attack against DNA, has been investigated. This derivative forms, with high fidelity, a dodecameric complex composed of three stacked G-quartets in the presence of strontium picrate. This is the first example of a fully-anti lipophilic G-quadruplex.
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