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Developing a mouse model of chronic ankle instability.

Erik A Wikstrom1, Tricia Hubbard-Turner, Sara Woods

  • 11Biodynamics Research Laboratory, Department of Kinesiology, University of North Carolina at Charlotte, Charlotte, NC; 2Center for Biomedical Engineering and Science, University of North Carolina at Charlotte, Charlotte, NC; and 3Laboratory of Systems Physiology, Department of Kinesiology, University of North Carolina at Charlotte, Charlotte, NC.

Medicine and Science in Sports and Exercise
|August 2, 2014
PubMed
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Ankle sprains in mice can lead to chronic ankle instability symptoms for up to 12 months. This study developed a mouse model to better understand and potentially prevent this common sports injury.

Area of Science:

  • Orthopedics
  • Sports Medicine
  • Animal Models

Background:

  • Ankle sprains are common in sports, often leading to chronic ankle instability (CAI).
  • Current clinical trials for CAI prevention are challenging due to cost and logistics.
  • An animal model is needed to study long-term CAI consequences and preclinical data.

Purpose of the Study:

  • To determine if surgically transecting lateral ankle ligaments in mice results in CAI-like symptoms 12 months post-injury.
  • To establish a reliable animal model for studying chronic ankle instability.

Main Methods:

  • Thirty male mice were divided into SHAM, mild (calcaneofibular ligament transection), and severe (anterior talofibular and calcaneofibular ligament transection) ankle sprain groups.
  • Mice ran on a wheel, and hind foot slips were recorded to assess balance and gait.

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  • Outcome measures were collected at baseline and several time points up to 60 weeks post-injury.

    • Main Results:

    • Mice with severe ankle sprains (ATFL/CFL) exhibited significantly more hind foot slips than mild (CFL) and control (SHAM) groups.
    • The severe sprain group also showed significantly reduced physical activity.
    • A threshold of 4.75 foot slips indicated CAI development in 70% of injured mice, with high specificity.

    Conclusions:

    • Surgical transection of lateral ankle ligaments in mice successfully induced CAI-like symptoms 12 months after injury.
    • This mouse model provides a viable platform for preclinical research into chronic ankle instability.