Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Local Anesthetics: Differential Sensitivity of Nerve Fibers01:24

Local Anesthetics: Differential Sensitivity of Nerve Fibers

1.7K
Local anesthetics (LAs) block the sodium channels of nerve trunks, sensory nerve endings, and neuromuscular junctions. Although LAs can block all kinds of nerves, the sensitivity of nerve fibers differs according to nerve types and structures. LAs are known to block myelinated fibers faster than unmyelinated ones. Also, they block pain or sensory neurons at low concentrations without affecting the motor neurons involved in muscle contractions. This helps relieve labor pain without affecting the...
1.7K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Cost of waiting: association of EEG delay and poor functional outcome in adult status epilepticus.

Journal of neurology, neurosurgery, and psychiatry·2026
Same author

Risk of recurrent ischemic stroke after non-cardioembolic ischemic stroke in England and Denmark.

Journal of neurology·2026
Same author

Predictors of relapses in patients with chronic inflammatory demyelinating polyneuropathy receiving subcutaneous immunoglobulin therapy - a post-hoc analysis.

Journal of neuromuscular diseases·2026
Same author

Differential Progression of Neuroinflammation in Patients with Isolated Rapid-Eye-Movement Sleep Behavior Disorder.

Movement disorders : official journal of the Movement Disorder Society·2026
Same author

Pre-hospital treatment duration and efficacy of remote ischaemic conditioning in the RESIST randomised-controlled trial.

European stroke journal·2026
Same author

Rates and risk factors for major adverse cardiovascular and cerebrovascular events after stroke due to intracerebral hemorrhage: Systematic review and study-level meta-analysis.

International journal of stroke : official journal of the International Stroke Society·2026

Related Experiment Video

Updated: Apr 26, 2026

Open-Source Real-Time Closed-Loop Electrical Threshold Tracking for Translational Pain Research
10:28

Open-Source Real-Time Closed-Loop Electrical Threshold Tracking for Translational Pain Research

Published on: April 21, 2023

3.1K

Spontaneous temporal changes and variability of peripheral nerve conduction analyzed using a random effects model.

Thomas Krøigård1, David Gaist, Marit Otto

  • 1*Department of Neurology, Odense University Hospital, Odense, Denmark.

Journal of Clinical Neurophysiology : Official Publication of the American Electroencephalographic Society
|August 2, 2014
PubMed
Summary

Nerve conduction studies in healthy adults show high reproducibility over six months. Key measures like peroneal nerve distal motor latency and motor conduction velocity remained stable, supporting their use in clinical trials.

More Related Videos

Functional and Physiological Methods of Evaluating Median Nerve Regeneration in the Rat
12:09

Functional and Physiological Methods of Evaluating Median Nerve Regeneration in the Rat

Published on: April 18, 2020

15.5K
Use of In Vivo Single-fiber Recording and Intact Dorsal Root Ganglion with Attached Sciatic Nerve to Examine the Mechanism of Conduction Failure
09:34

Use of In Vivo Single-fiber Recording and Intact Dorsal Root Ganglion with Attached Sciatic Nerve to Examine the Mechanism of Conduction Failure

Published on: August 27, 2019

8.2K

Related Experiment Videos

Last Updated: Apr 26, 2026

Open-Source Real-Time Closed-Loop Electrical Threshold Tracking for Translational Pain Research
10:28

Open-Source Real-Time Closed-Loop Electrical Threshold Tracking for Translational Pain Research

Published on: April 21, 2023

3.1K
Functional and Physiological Methods of Evaluating Median Nerve Regeneration in the Rat
12:09

Functional and Physiological Methods of Evaluating Median Nerve Regeneration in the Rat

Published on: April 18, 2020

15.5K
Use of In Vivo Single-fiber Recording and Intact Dorsal Root Ganglion with Attached Sciatic Nerve to Examine the Mechanism of Conduction Failure
09:34

Use of In Vivo Single-fiber Recording and Intact Dorsal Root Ganglion with Attached Sciatic Nerve to Examine the Mechanism of Conduction Failure

Published on: August 27, 2019

8.2K

Area of Science:

  • Neuroscience
  • Clinical Electrophysiology

Background:

  • Peripheral nerve conduction studies are crucial for diagnosing neurological disorders.
  • Assessing the reproducibility of these measures in healthy individuals is essential for reliable clinical trial design.

Purpose of the Study:

  • To analyze the temporal changes and variability of standard nerve conduction measures in the leg using a random effects regression model.
  • To determine the reproducibility of peroneal, sural, and tibial nerve conduction parameters in healthy adults over a 6-month period.

Main Methods:

  • Examined peroneal nerve distal motor latency, motor conduction velocity, and compound motor action potential amplitude.
  • Assessed sural nerve sensory action potential amplitude and sensory conduction velocity.
  • Measured tibial nerve minimal F-wave latency in 51 healthy subjects (aged 40-67) at baseline, 2 weeks, and 26 weeks.

Main Results:

  • Most nerve conduction variables showed no significant change over 6 months, with minor decreases in sural nerve sensory action potential amplitude and increases in tibial nerve minimal F-wave latency.
  • Peroneal nerve distal motor latency and motor conduction velocity, sural nerve sensory conduction velocity, and tibial nerve minimal F-wave latency demonstrated the highest reproducibility.
  • Between-subject variability exceeded within-subject variability, indicating consistent individual measurements.

Conclusions:

  • Nerve conduction studies exhibit high reproducibility and stability in healthy adults over six months.
  • The findings provide a robust foundation for designing future clinical trials that assess nerve conduction changes.
  • Calculated sample sizes suggest that 21 to 128 subjects are needed to detect changes twice the magnitude of spontaneous variations.