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Serum cystatin C levels are associated with coronary artery disease and its severity

Gan-nan Wang1, Kai Sun1, De-liang Hu1

  • 1Department of Emergency, The First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu 210029, PR China.

Clinical Biochemistry
|August 2, 2014
PubMed

Insights

Elevated serum cystatin C levels are linked to coronary artery disease (CAD) presence and severity in individuals with normal kidney function. This suggests cystatin C may aid in CAD diagnosis and severity assessment.

Area of Science:

  • Cardiology
  • Biomarkers
  • Renal Function

Background:

  • Serum cystatin C is a known predictor of cardiovascular events.
  • Its role in determining coronary artery disease (CAD) presence and severity requires further elucidation.

Purpose of the Study:

  • To evaluate the association between serum cystatin C levels and the presence of CAD.
  • To assess the correlation of cystatin C with the severity of CAD in patients with normal renal function.

Main Methods:

  • Cross-sectional study of 936 subjects (714 with CAD, 222 without) based on coronary angiography.
  • Serum cystatin C measured via particle-enhanced immunoassay.
  • Analysis of cystatin C levels against CAD presence, number of stenotic vessels, and Gensini score.

Main Results:

  • Significantly higher serum cystatin C in CAD patients (P<0.001).
  • Cystatin C levels increased with coronary vessel involvement and Gensini score (P<0.001).
  • Independent correlation of cystatin C with CAD presence (P=0.023) and positive correlation with Gensini score (P=0.010).

Conclusions:

  • Elevated serum cystatin C is significantly associated with CAD presence and severity in patients with normal renal function.
  • Cystatin C may serve as a valuable diagnostic marker and severity indicator for CAD.
Abstract

Keywords:
Coronary artery diseaseCystatin CGensini scoreGlomerular filtration rate

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