Related Experiment Video
Updated: Apr 26, 2026

In Vitro Microfluidic Disease Model to Study Whole Blood-Endothelial Interactions and Blood Clot Dynamics in Real-Time
Published on: May 24, 2020
[Chronic thromboembolic pulmonary hypertension--a position paper]
H Wilkens1, I Lang2, T Blankenburg3
1Klinik für Innere Medizin V, Universitätsklinikum des Saarlandes, Homburg.
This paper outlines chronic thromboembolic pulmonary hypertension (CTEPH) diagnosis and treatment, emphasizing pulmonary endarterectomy (PEA) for operable cases. PEA offers better long-term survival and quality of life compared to medical therapy for CTEPH patients.
Area of Science:
- Cardiology
- Pulmonology
- Vascular Surgery
Background:
- Summarizes current developments in chronic thromboembolic pulmonary hypertension (CTEPH).
- Based on 2013 Nice 5th World Symposium on Pulmonary Hypertension guidelines.
- Addresses open questions in CTEPH patient management.
Framework:
- Recommends echocardiography and cardiopulmonary exercise testing for suspected CTEPH.
- Ventilation/perfusion scan is the primary imaging screening tool.
- Emphasizes multidisciplinary expert center evaluation for treatment decisions.
Implementation:
- Pulmonary endarterectomy (PEA) is the preferred treatment for operable CTEPH.
- Medical therapy is reserved for inoperable cases or post-PEA residual disease.
- Initiate medical therapy only if PEA is not an option.
Implications:
- CTEPH patients undergoing PEA demonstrate superior long-term survival rates.
- PEA treatment leads to an improved quality of life in CTEPH patients.
- Highlights the importance of surgical intervention for optimal CTEPH outcomes.
Related Concept Videos
Pulmonary Embolism I: Introduction
Pulmonary Embolism I: Introduction
Pulmonary Embolism II: Diagnostic Studies and Interprofessional Care
Pulmonary Embolism III: Nursing Management
Pulmonary Hypertension: Classification and Pathogenesis
There are various classifications for PH, each relating to different underlying causes and also...
Treatment for Pulmonary Arterial Hypertension: Receptor Tyrosine Kinase Inhibitors and Calcium Channel Blockers
TKIs, such as imatinib (Gleevec), are particularly effective in tackling the growth and mitogenic factors that become upregulated in PAH patients. These factors contribute to the...

