Related Experiment Video
Updated: Apr 26, 2026

Coherence between Brain Cortical Function and Neurocognitive Performance during Changed Gravity Conditions
Published on: May 23, 2011
Risk neurogenes for long-term spaceflight: dopamine and serotonin brain system
N K Popova1, A V Kulikov, E M Kondaurova
1Department of Behavioral Neurogenomics, Institute of Cytology and Genetics, Lavrentyeva avenue, 10, Novosibirsk, Russia, 633090.
Abstract:
Mice were exposed to 1 month of spaceflight on Russian biosatellite BION-M1 to determine its effect on the expression of key genes in the brain dopamine (DA) and serotonin (5-HT) systems. Spaceflight decreased the expression of crucial genes involved in DA synthesis and degradation, as well as the D1 receptor. However, spaceflight failed to alter the expression of tryptophan hydroxylase-2, 5-HT transporter, 5-HT1A, and 5-HT3 receptor genes, though it reduced 5-HT2A receptor gene expression in the hypothalamus. We revealed risk DA and 5-HT neurogenes for long-term spaceflight for the first time, as well as microgravity-responsive genes (tyrosine hydroxylase, catechol-O-methyltransferase, and D1 receptor in the nigrostriatal system; D1 and 5-HT2A receptors in the hypothalamus; and monoamine oxidase A (MAO A) in the frontal cortex). Decreased genetic control of the DA system may contribute to the spaceflight-induced locomotor impairment and dyskinesia described for both humans and rats.
More Related Videos
Related Concept Videos
Drugs Affecting Neurotransmitter Synthesis
Neurogenesis and Regeneration of Nervous Tissue
Drugs Affecting Neurotransmitter Release or Uptake
Gut-Brain Axis

