Non-rash dermatologic adverse events related to targeted therapies

Area of Science:

• Dermatology
• Oncology
• Pharmacology

Background:

• Targeted therapies have increased, leading to various dermatological adverse events.
• Non-rash events like xerosis, pruritus, and hand-foot skin reaction are common.
• These events can significantly impact patient quality of life.

Purpose of the Study:

• To synthesize background information on non-rash dermatological adverse events.
• To outline management strategies for these side effects.
• To provide guidance for clinical practice and nursing.

Main Methods:

• Literature review of peer-reviewed journal articles.
• Consultation of professional manuals and online resources.
• Synthesis of reported adverse events and management recommendations.

Main Results:

• Numerous dermatological adverse events associated with targeted therapy are reported.
• Common events include xerosis, skin fissures, pruritus, photosensitivity, and hair/nail changes.
• Severe events like Stevens-Johnson syndrome and toxic epidermal necrolysis also occur.

Conclusions:

• Evidence-based treatment options for these adverse events are limited.
• Numerous practical recommendations are available in the literature.
• Education, assessment, and management are crucial for enhancing nursing practice and patient care.