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Updated: Apr 26, 2026
Trans-Tympanic Drug Delivery for the Treatment of Ototoxicity
Published on: March 16, 2018
Optic and otic side effects of molecular targeted therapies
Objectives:
To discuss the optic and otic toxicities associated with molecular targeted therapies including description, presentation, grading, and management of these toxicities.
Data Sources:
PubMed, CINAHL, the Cochrane Library and nursing text books.
Conclusion:
Although targeted therapies often do not have the same systemic toxicities as chemotherapy, they have their own unique side effects. Optic and otic toxicities are seen with a variety of targeted therapies and, although these are not life-threatening toxicities, they do have the potential to severely impair a patient's quality of life.
Implications For Nursing Practice:
Baseline optic and otic assessments along with periodic assessments throughout treatment can lead to early recognition of problems with the eyes or ears. Recognition and treatment of these problems will help maintain the patient's quality of life.
Insights
Molecular targeted therapies can cause unique optic and otic toxicities that impact patient quality of life. Early recognition and management of these side effects are crucial for maintaining well-being.
Area of Science:
- Oncology
- Ophthalmology
- Otolaryngology
Background:
- Molecular targeted therapies offer novel treatment strategies in oncology.
- While often having fewer systemic side effects than traditional chemotherapy, targeted therapies present unique toxicity profiles.
- Ocular and auditory toxicities are emerging concerns with these advanced treatments.
Purpose of the Study:
- To review the optic and otic toxicities associated with molecular targeted therapies.
- To describe the presentation, grading, and management strategies for these specific side effects.
Main Methods:
- Literature search conducted using PubMed, CINAHL, and the Cochrane Library.
- Relevant nursing textbooks were also consulted for comprehensive information.
Main Results:
- Targeted therapies, while distinct from chemotherapy, can induce specific ocular and auditory toxicities.
- These toxicities, though not typically life-threatening, significantly affect patient quality of life.
Conclusions:
- Optic and otic toxicities are recognized side effects of various targeted therapies.
- Implementing baseline and periodic assessments for ocular and auditory health is vital for early detection.
- Prompt recognition and intervention are essential for preserving patients' quality of life during treatment.
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