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Updated: Apr 26, 2026
Author Spotlight: Enhancing Skin Model Diversity with Cost-Effective 3D Cellular Models
Published on: October 20, 2023
Clinical applications of skin substitutes
Theodore T Nyame1, H Abraham Chiang2, Dennis P Orgill3
1Brigham and Women's Hospital, 75 Francis Street, Boston, MA 02115, USA.
Abstract:
A unique understanding of the components of mammalian skin has led to the development of numerous skin substitutes. These skin substitutes attempt to compensate for functional and physiologic deficits present in damaged tissue. Skin substitutes, when appropriately applied in optimized settings, offer a promising solution to difficult wound management. The body of literature on skin substitutes increases as the understanding of tissue engineering and molecular biology expands. Given the high cost of these products, future randomized large prospective studies are needed to guide the clinical applications of skin substitutes.
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