Related Experiment Video
Updated: Apr 26, 2026

Rapid In Situ Hybridization using Oligonucleotide Probes on Paraformaldehyde-prefixed Brain of Rats with Serotonin Syndrome
Published on: September 23, 2015
Beyond genotype: serotonin transporter epigenetic modification predicts human brain function
Yuliya S Nikolova1, Karestan C Koenen2, Sandro Galea2
1Laboratory of NeuroGenetics, Department of Psychology &Neuroscience, and Institute for Genome Sciences &Policy, Duke University, Durham, North Carolina, USA.
Abstract:
We examined epigenetic regulation in regards to behaviorally and clinically relevant human brain function. Specifically, we found that increased promoter methylation of the serotonin transporter gene predicted increased threat-related amygdala reactivity and decreased mRNA expression in postmortem amygdala tissue. These patterns were independent of functional genetic variation in the same region. Furthermore, the association with amygdala reactivity was replicated in a second cohort and was robust to both sampling methods and age.
Related Concept Videos
Human Genetics
The complex relationship between genetics and psychology is observable through common biological components such...
Pharmacogenetics of Drug Transporters: P-Glycoprotein and Solute Carrier Transporters
Regulated mRNA Transport
Pharmacogenetics of Drug Targets: β₂-Adrenergic Receptors, Apo E, Thymidylate Synthase
The Significance of Membrane Transport
Transporters facilitate either an active or passive movement of solutes. They can allow a single-molecule transport down its...
Drugs Affecting Neurotransmitter Release or Uptake

