[Infant pain response according to vaccine administration]

To determine if acute pain response in infants after administration of pentavalent diphtheria (polio, tetanus, acellular pertussis and B Type Hemophilus influenzae: Pentavac) and meningitis C vaccine (NeisVacC) vary according to the administration order.

A multicenter, randomized control trial, double-blind was performed in three pediatric nursing consultations of three healthcare centers between December 2010, and December 2011. Two months healthy children in subjected to a routine immunization. Routine immunizations are given in a different order to children; first NeisVac C and then Pentavac are given to the Group A and first Pentavac and then NeisVac C are given to the Group B. Was measured infant pain during the injection of the vaccine using a validates method, the Modified Behavioral Pain Scale (MBPS). Parents measured pain with the VAS scale and evaluated the presence of tears before the beginning of vaccination.

Within the 184 infants, 92 received the A order, and 92 the B order. There were no differences between groups in terms of sociodemographic characteristics. The average (AV) pain scores per infant after receiving injections were significantly lower when Pentavac was administered in a second place in A Group. MBPS 5.6 (SD 1.5) versus NeisVac C 7.6 (SD 1.3) (p = 0.0001), EVA 3.6 Parents (SD) versus 5.4 (DE 1.9) (p = 0.0001). In B Group, the average for Pentavac" BPS pain was 7.6 (SD 1.5) versus 7.9 (DE 1.2) to NeisVac C Parents EVA 5.5 (SD 1.8) versus 6.3 (SD 1.6) (p = 0.004).

Pain was reduced when Pentavac vaccine was administered before NeisVac C in infants subjected to a routine vaccination. It is recommended that the order of injections of the vaccine will be first Pentavac followed by NeisVac C.