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Significant pericardial involvement of immunoglobulin G4-related disease

Takehiro Morita1, Atsushi Izawa1, Hideaki Hamano2

  • 1Department of Cardiovascular Medicine, Shinshu University School of Medicine, Matsumoto, Japan.

The Annals of Thoracic Surgery
|August 5, 2014
PubMed

A 60-year-old woman was hospitalized with cardiac tamponade due to effusive pericarditis presenting with significant thickening of the pericardium. Serum immunoglobulin G4 (IgG4) level was elevated to 1,800 mg/dL, and an open biopsy specimen from the pericardium revealed massive infiltration of lymphocytes and IgG4-positive plasma cells. She had experienced adenopathies in the lacrimal and parotid glands 6 months earlier, and was diagnosed as having IgG4-related Mikulicz's disease by similar cell infiltration in the salivary gland biopsy. The significant involvement of the pericardium as a manifestation of IgG4-related disease is described, as well as the successful treatment with oral corticosteroids.

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