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The bm12 Inducible Model of Systemic Lupus Erythematosus SLE in C57BL/6 Mice
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IL-21 acts as a promising therapeutic target in systemic lupus erythematosus by regulating plasma cell
Cellular & Molecular Immunology
|August 5, 2014
Abstract:
Plasma cells, which secrete auto-antibodies, are considered to be the arch-criminal of autoimmune diseases such as systemic lupus erythematosus, but there are many cytokines involved in inducing the differentiation of B-cell subsets into plasma cells. Here, we emphasize IL-21, which has emerged as the most potent inducer of plasma cell differentiation. In this review, we focused on the promoting effects of IL-21 on plasma cell differentiation and discuss how these effects contribute to B cell-mediated autoimmune disease.
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