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Multisession gamma knife radiosurgery: a preliminary experience with a noninvasive, relocatable frame
James H Nguyen1, Ching-Jen Chen1, Cheng-Chia Lee1
1Department of Neurological Surgery, University of Virginia Health System, Charlottesville, Virginia, USA.
World Neurosurgery
|August 5, 2014
Summary
Multisession Gamma Knife radiosurgery (GKRS) using a noninvasive system shows promising tumor control for brain tumors. This technique offers a safe option with manageable side effects, potentially expanding treatment options.
Area of Science:
- Neurosurgery
- Radiation Oncology
- Medical Physics
Background:
- Multisession Gamma Knife radiosurgery (GKRS) is an evolving technique for treating intracranial pathologies.
- Evaluating novel immobilization systems is crucial for optimizing radiosurgical delivery and patient outcomes.
Purpose of the Study:
- To assess the preliminary outcomes of multisession GKRS using a new noninvasive vacuum-assisted immobilization system.
- To determine the efficacy and safety of this approach for various intracranial tumors.
Main Methods:
- A retrospective review of 15 patients treated with multisession GKRS for tumors including meningiomas and pituitary adenomas.
- GKRS was delivered in 3-5 sessions, with detailed dose and volume parameters recorded.
- Follow-up included regular examinations to monitor tumor control and adverse events.
Main Results:
- All 15 patients achieved tumor control, with 5 showing regression and 10 demonstrating stability.
- Three patients experienced temporary neurologic deficits, and minor complications like ptosis and taste dysfunction resolved without permanent sequelae.
- No patients developed vision deterioration during the follow-up period.
Conclusions:
- Multisession GKRS with the noninvasive system demonstrates promising tumor control and acceptable complication rates.
- This technique may broaden the applicability of stereotactic radiosurgery for complex intracranial lesions, including larger tumors and those near critical structures.
