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Hashimoto's disease is a frequent comorbidity and an exacerbating factor of chronic spontaneous urticaria

A Sugiyama1, H Nishie1, S Takeuchi2

  • 1Department of Dermatology, National Fukuoka Hospital, National Hospital Organization, 4-39-1, Yakatabaru, Minami-ku, Fukuoka 811-1394, Japan.

Allergologia Et Immunopathologia
|August 5, 2014
PubMed

Insights

Chronic spontaneous urticaria (CSU) frequently co-occurs with Hashimoto's disease (HD). Treating HD in CSU patients led to symptom remission, suggesting HD may influence CSU's cause or severity.

Area of Science:

  • Immunology
  • Dermatology
  • Endocrinology

Background:

  • The exact cause of chronic spontaneous urticaria (CSU) is unknown.
  • CSU is often associated with autoimmune conditions like Hashimoto's disease (HD).
  • This study explored the link between CSU, HD, and autoreactivity.

Purpose of the Study:

  • To determine the frequency of HD comorbidity in CSU patients.
  • To assess autoreactivity in CSU patients with HD.
  • To evaluate the effect of thyroid therapy on CSU symptoms in patients with HD.

Main Methods:

  • Evaluated 40 CSU patients for thyroid autoantibodies and hormone levels.
  • Administered thyroid therapy to diagnosed HD patients and monitored urticarial symptoms.
  • Used autologous serum skin test (ASST) to assess autoreactivity.

Main Results:

  • 11 of 40 CSU patients had HD.
  • 5 of 7 CSU patients with HD had positive ASST results, compared to 2 of 6 without HD.
  • 4 of 5 patients with HD who received thyroid therapy showed significant symptom improvement.

Conclusions:

  • CSU patients exhibit a high rate of HD comorbidity and a tendency for positive ASST.
  • Thyroid therapy can significantly improve CSU symptoms in patients with HD.
  • HD may play a role in CSU's development or act as an exacerbating factor.
Abstract

Keywords:
Autoimmune urticariaAutoreactivityChronic spontaneous urticariaHashimoto's diseaseThyroid autoantibodiesThyroid hormone

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