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Updated: Apr 26, 2026
A Precision Medicine Tool for Measurement and Monitoring of Hemoglobin S in Sickle Cell Disease Patients Receiving Transfusion Therapy
Severe anemia in an adolescent male with sickle cell trait: a case report
Adrian Chapa-Rodriguez1, Dipti Dighe, Lisa Giordano
1Division of Pediatric Hematology/Oncology, Department of Pediatrics, John H. Stroger Jr. Hospital of Cook County, Chicago, IL.
Background:
Sickle cell trait is generally considered a benign condition. However, it has been associated with uncommon comorbidities such as painless gross hematuria secondary to renal papillary necrosis and renal medullary carcinoma.
Observation:
We present a 16-year-old African American boy with sickle cell trait and a recent history of prolonged gross hematuria due to renal papillary necrosis. The patient developed severe iron deficiency anemia and required transfusion support.
Conclusions:
Although renal papillary necrosis is well-described, it is uncommon in pediatrics and only rarely results in the need for transfusion.
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