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[Axon regeneration in the Trembler mouse, with mutation affecting Schwann cells]
B Ferzaz1, H Koenig, A Ressouches
1Université de Bordeaux-I, C.N.R.S. U.R.A. n 1126, Laboratoire de Neurologie du Développement, Talence.
Abstract:
Elongation, branching and regeneration rate of axons are increased (two folds) in Trembler tibial nerve after local freezing and control grafting (NNN; TrTrTr). After chimera transplantation (NTrN), normal regenerating axons are increased by 50% when they grow within a mutant (Tr) as compared to a normal (N) graft. Our results emphasize the influence of the density of Schwann cells and multi-layered basal laminas which characterize Trembler peripheral nerves.