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Assembly and Characterization of Polyelectrolyte Complex Micelles
Published on: March 2, 2020
Catch and Release: Photocleavable Cationic Diblock Copolymers as a Potential Platform for Nucleic Acid Delivery
Matthew D Green1, Abbygail A Foster1, Chad T Greco1
1Department of Chemical and Biomolecular Engineering, University of Delaware, Newark, DE 19716, USA. ; Tel: +1 302 831 8072.
Abstract:
Binding interactions between DNA and cationic carriers must be sufficiently strong to prevent nuclease-mediated degradation, yet weak enough to permit transcription. We demonstrate cationic diblock copolymers containing PEG and o-nitrobenzyl moieties that facilitated tailorable DNA complexation and light-activated release. This design unlocks a new approach to advance non-viral gene packaging.
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