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Updated: Apr 26, 2026

Comparing the Affinity of GTPase-binding Proteins using Competition Assays
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Detecting "different": Pyrin senses modified GTPases

Marcel R de Zoete1, Richard A Flavell1

  • 11] Department of Immunobiology, Yale University School of Medicine, New Haven, CT 06520, USA [2] Howard Hughes Medical Institute, Yale University, New Haven, CT 06520, USA.

Cell Research
|August 6, 2014
PubMed
Summary

Pathogenic bacteria use effector proteins to disrupt host cell actin cytoskeleton. A new study reveals the Pyrin inflammasome acts as a sensor for this bacterial attack, offering insights into host defense mechanisms.

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