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The effect of tranexamic acid on artificial joint materials: a biomechanical study (the bioTRANX study)
Sattar Alshryda1, James M Mason, Praveen Sarda
1Departments of Trauma and Orthopaedics, Central Manchester University Hospitals, Oxford Road, Manchester, M13 9WL, Lancashire, UK, Sattar26@doctors.org.uk.
Background:
Tranexamic acid (TXA) has been successfully used to reduce bleeding in joint replacement. Recently local TXA has been advocated to reduce blood loss in total knee or hip replacement; however, this raised concerns about potential adverse effects of TXA upon the artificial joint replacement.
Materials And Methods:
In this biomechanical study we compared the effects of TXA and saline upon the following biomechanical properties of artificial joint materials-(1) tensile properties (ultimate strength, stiffness and Young's modulus), (2) the wear rate using a multi-directional pin-on-plate machine, and (3) the surface topography of pins and plates before and after wear rate testing.
Results:
There were no significant differences in tensile strength, wear rates or surface topography of either ultra-high-molecular-weight polyethylene pins or cobalt chromium molybdenum metal plates between specimens soaked in TXA and specimens soaked in saline.
Conclusion:
Biomechanical testing shows that there are no biomechanical adverse affects on the properties of common artificial joint materials from using topical TXA.
Level Of Evidence:
V.
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