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Severity of rotavirus gastroenteritis in an Indian population: report from a 3 year surveillance study

Ann Mathew1, P S Sundar Rao2, Thuppal V Sowmyanarayanan3

  • 1Department of Pediatrics, St. Stephens' Hospital, Delhi, India.

Vaccine
|August 6, 2014
PubMed

Insights

Rotavirus gastroenteritis (RVGE) is severe in infants under six months. This study found younger infants experienced worse outcomes, highlighting the need for early rotavirus immunization.

Area of Science:

  • Pediatrics
  • Infectious Diseases
  • Vaccinology

Background:

  • Rotavirus gastroenteritis (RVGE) is a leading cause of severe diarrheal disease in infants and young children globally.
  • Hospitalization data is crucial for understanding the burden of severe RVGE in vulnerable populations.

Purpose of the Study:

  • To investigate the severity of rotavirus gastroenteritis (RVGE) in hospitalized children under 60 months of age.
  • To compare RVGE severity in infants aged 0-5 months versus children aged 6-23 months.

Main Methods:

  • A 3-year surveillance study was conducted.
  • Data collected included RVGE hospitalizations and clinical severity indicators.
  • Comparison of disease severity between infants (0-5 months) and older children (6-23 months).

Main Results:

  • An early peak of rotavirus disease was observed, with 31% of RVGE hospitalizations occurring in infants under 6 months.
  • Infants aged 0-5 months exhibited higher incidences of severe dehydration, acidemia, and acidosis upon admission.
  • Younger infants also experienced prolonged hospitalizations exceeding 7 days.

Conclusions:

  • Infants in the first five months of life are particularly vulnerable to severe rotavirus gastroenteritis.
  • Findings support the need for timely rotavirus immunization, potentially including an accelerated schedule or a birth dose.
  • Early vaccination is critical to protect this high-risk age group from severe RVGE outcomes.

Keywords:
AcidosisElectrolytesInfancyRotavirusVaccine

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