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Updated: Apr 26, 2026
Xenograft Skin Model to Manipulate Human Immune Responses In Vivo
Published on: June 29, 2022
Long-term maintenance of skin immune system in a NOD-Scid IL2rγ(null) mouse model transplanted with human skin
Angèle Soria1, David Boccara, Louis Chonco
1Centre d'Immunologie et des Maladies Infectieuses Cimi-Paris, Sorbonne Universités, UPMC Univ. Paris 06, UMR_S CR7, Paris, France; INSERM U1135, Cimi-Paris, Paris, France; Service de dermatologie et allergologie, hôpital Tenon, Assistance Publique Hôpitaux de Paris, Paris, France.
We developed a NOD-Scid IL2rγ(null) mouse model transplanted with human skin that brings fundamental insight on in vivo cellular mechanisms of intradermal immunization and antigen presentation by dermal dendritic and epidermal Langerhans cells for skin T-cell immunity. Indeed, T-cell immunity is a crucial checkpoint for the induction of in vivo rapid control of skin infection. With the long-term preservation of a complete human skin immune system, this model offers the unique opportunity not only to better understand mechanisms of skin immune response but also to test new compounds and devices for cutaneous routes of vaccination, as well as new therapeutics approach for skin diseases, allergies or infections.
We developed a NOD-Scid IL2rγ(null) mouse model transplanted with human skin that brings fundamental insight on in vivo cellular mechanisms of intradermal immunization and antigen presentation by dermal dendritic and epidermal Langerhans cells for skin T-cell immunity. Indeed, T-cell immunity is a crucial checkpoint for the induction of in vivo rapid control of skin infection. With the long-term preservation of a complete human skin immune system, this model offers the unique opportunity not only to better understand mechanisms of skin immune response but also to test new compounds and devices for cutaneous routes of vaccination, as well as new therapeutics approach for skin diseases, allergies or infections.
