Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Ischemic Heart Disease: Overview01:17

Ischemic Heart Disease: Overview

3.8K
Ischemic heart disease occurs when the heart's blood supply dwindles, causing an ominous lack of oxygen and nutrients. This deficiency, stemming from reduced or obstructed blood flow, spells danger, leading to heart muscle damage and dysfunction.
Atherosclerosis, the primary malefactor, orchestrates this dangerous condition. It manifests as the accumulation of fatty deposits, akin to insidious plaques, within arterial walls. As time elapses, these plaques metamorphose, hardening and...
3.8K
Ischemic Stroke l: Introduction01:15

Ischemic Stroke l: Introduction

29
Ischemic stroke is an acute cerebrovascular condition in which blood flow to a brain region is suddenly interrupted, leading to tissue infarction. Neurons depend on continuous oxygen and glucose supply, so even brief reductions in perfusion cause energy failure, ionic imbalance, and irreversible injury. Ischemic strokes are classified into thrombotic and embolic types based on their underlying mechanisms.Thrombotic MechanismsThrombotic stroke develops when a clot forms within a cerebral artery.
29
Ischemic Stroke ll: Pathophysiology01:15

Ischemic Stroke ll: Pathophysiology

42
An ischemic stroke occurs when a cerebral blood vessel becomes obstructed, most often by a thrombus or embolus, interrupting the delivery of oxygen and glucose to brain tissue. Because neurons rely on continuous aerobic metabolism, energy failure begins within minutes of reduced perfusion. The region receiving the least blood flow becomes the infarct core, an area of irreversible cellular death. Surrounding this core lies the penumbra, a zone of hypoperfused but still viable tissue that is...
42
Acute Coronary Syndrome I: Introduction01:30

Acute Coronary Syndrome I: Introduction

2.0K
Acute Coronary Syndrome (ACS) encompasses a spectrum of heart conditions caused by sudden obstruction of coronary arteries, typically resulting from the rupture of an atherosclerotic plaque and subsequent thrombus (blood clot) formation. This obstruction can lead to partial or complete blockage of blood flow, causing varying degrees of myocardial ischemia or infarction.ACS includes the following clinical entities:Unstable Angina (UA)Non-ST-Elevation Myocardial Infarction (NSTEMI)ST-Elevation...
2.0K
Transient Ischemic Attack l: Introduction01:26

Transient Ischemic Attack l: Introduction

13
A transient ischemic attack (TIA) is a brief episode of neurological dysfunction caused by a temporary, focal reduction in cerebral blood flow. Although symptoms resemble those of an ischemic stroke, the interruption in perfusion is short-lived and does not cause permanent infarction. TIAs are clinically important because they often serve as early warning events for future stroke.Mechanisms of Transient Cerebral IschemiaTransient cerebral ischemia may arise through several mechanisms. One...
13
Angina II: Classification01:27

Angina II: Classification

703
Angina, also known as angina pectoris, is a chest pain resulting from diminished blood flow to the heart muscle and is often a symptom of coronary artery disease. Angina presents several variants with distinctive attributes, etiologies, and therapeutic approaches. The main types of angina include stable, unstable, variant (Prinzmetal's), microvascular, intractable, and silent ischemia.Stable angina is caused by atherosclerosis, which leads to the formation of plaques that narrow the coronary...
703

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Beneficial effects of prehospital use of statins in a large United States cohort of hospitalized coronavirus disease 2019 patients.

Journal of cardiovascular medicine (Hagerstown, Md.)·2023
Same author

Second Consensus on Treatment of Patients Recently Diagnosed With Mild Hypertension and Low Cardiovascular Risk.

Current problems in cardiology·2020
Same author

Trends in Guideline-Driven Revascularization in Diabetic Patients with Multivessel Coronary Heart Disease.

Journal of cardiovascular development and disease·2019
Same author

Lipoprotein(a): Current Evidence for a Physiologic Role and the Effects of Nutraceutical Strategies.

Clinical therapeutics·2019
Same author

Cardiac rehabilitation underutilization: Missed opportunities in comprehensive cardiac care.

International journal of cardiology·2019
Same author

Concerning the degradation of β-blocker use in the 2018 ESC/ESH hypertension guidelines.

European heart journal·2019

Related Experiment Video

Updated: Apr 26, 2026

Murine Isolated Heart Model of Myocardial Stunning Associated with Cardioplegic Arrest
08:30

Murine Isolated Heart Model of Myocardial Stunning Associated with Cardioplegic Arrest

Published on: August 6, 2015

11.2K

Stable ischemic heart disease.

Richard Kones1, Umme Rumana1

  • 1The Cardiometabolic Research Institute, 8181 Fannin Street, Unit 314, Houston, TX 77054, USA.

Cardiology Clinics
|August 6, 2014
PubMed
Summary
This summary is machine-generated.

Classical angina, characterized by chest discomfort, stems from an oxygen supply-demand imbalance. Effective management focuses on improving quality of life and preventing future cardiac events through lifestyle changes and medical advancements.

Keywords:
AnginaCalcium channel blockersCardiovascular risk assessmentCoronary artery diseaseMyocardial oxygen balanceNitratesSilent ischemiaStable ischemic heart diseaseβ-Blockers

More Related Videos

A Research Method For Detecting Transient Myocardial Ischemia In Patients With Suspected Acute Coronary Syndrome Using Continuous ST-segment Analysis
18:11

A Research Method For Detecting Transient Myocardial Ischemia In Patients With Suspected Acute Coronary Syndrome Using Continuous ST-segment Analysis

Published on: December 28, 2012

23.8K
Simultaneous Photothrombosis and Fiber Photometry to Induce and Monitor Ischemic Stroke in Behaving Mice
07:49

Simultaneous Photothrombosis and Fiber Photometry to Induce and Monitor Ischemic Stroke in Behaving Mice

Published on: November 14, 2025

686

Related Experiment Videos

Last Updated: Apr 26, 2026

Murine Isolated Heart Model of Myocardial Stunning Associated with Cardioplegic Arrest
08:30

Murine Isolated Heart Model of Myocardial Stunning Associated with Cardioplegic Arrest

Published on: August 6, 2015

11.2K
A Research Method For Detecting Transient Myocardial Ischemia In Patients With Suspected Acute Coronary Syndrome Using Continuous ST-segment Analysis
18:11

A Research Method For Detecting Transient Myocardial Ischemia In Patients With Suspected Acute Coronary Syndrome Using Continuous ST-segment Analysis

Published on: December 28, 2012

23.8K
Simultaneous Photothrombosis and Fiber Photometry to Induce and Monitor Ischemic Stroke in Behaving Mice
07:49

Simultaneous Photothrombosis and Fiber Photometry to Induce and Monitor Ischemic Stroke in Behaving Mice

Published on: November 14, 2025

686

Area of Science:

  • Cardiology
  • Internal Medicine
  • Clinical Therapeutics

Background:

  • Classical angina presents as substernal discomfort, typically triggered by exertion or emotional stress.
  • The underlying pathophysiology involves an imbalance between myocardial oxygen supply and demand.
  • Therapeutic objectives include enhancing patient quality of life, preventing mortality, and mitigating disease progression.

Purpose of the Study:

  • To review recent advancements in understanding and managing classical angina.
  • To highlight the impact of new pathophysiological insights, pharmacological agents, and technological innovations on patient care.
  • To emphasize the role of behavioral modifications in cardiovascular risk factor management.

Main Methods:

  • Review of current literature on angina pathophysiology and treatment.
  • Analysis of recent pharmacological and technological developments.
  • Evaluation of the efficacy of lifestyle interventions in cardiac rehabilitation.

Main Results:

  • Significant improvements in patient care over the last decade due to new data and therapies.
  • Behavioral changes, including diet modification, increased physical activity, and adherence to cardiac rehabilitation, are effective.
  • Despite challenges in implementation, lifestyle interventions are crucial for long-term management.

Conclusions:

  • Modern therapeutic strategies have enhanced the management of classical angina.
  • A multi-faceted approach combining pharmacological treatments, technological advances, and behavioral changes is essential.
  • Patient adherence to lifestyle modifications and cardiac rehabilitation programs is key to improving outcomes and slowing disease progression.